Advanced Solid Tumors, Excluding Breast Cancer

Ovarian Cancer

Primary Myelofibrosis, Post-Polycythemia Vera, Post-Essential Thrombocythemia Myelofibrosis

Advanced and Selected Solid Tumors

Small Cell Lung Carcinoma

Colorectal Cancer, Squamous Cell Head and Neck Cancer, Non-small Cell Lung Cancer, Triple Negative Breast Cancer, Other Tumors With EGFR Dependence

Nonhematologic Malignancies, Lymphoma

Endometrial Carcinoma

Cancer

Squamous Cell Carcinoma of the Head and Neck

Leukemia, Pediatric

Childhood Cerebral Astrocytoma/Malignant Glioma, Childhood High-grade Cerebellar Astrocytoma, Childhood High-grade Cerebral Astrocytoma, Childhood Infratentorial Ependymoma, Childhood Mixed Glioma, Childhood Oligodendroglioma, Childhood Supratentorial Ependymoma, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Subependymal Giant Cell Astrocytoma

Major Depressive Disorder

Crohn's Disease

Ulcerative Colitis

Colorectal Cancer

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, Gliosarcoma, Glioblastoma With Oligodendroglial Component

Pancreatic Cancer

Papulopustular Rosacea (PPR)

ST Segment Elevation Myocardial Infarction

Cancer Patients With Solid Tumors

Glioblastoma, Small Cell Glioblastoma, Giant Cell Glioblastoma, Gliosarcoma, Glioblastoma With Oligodendroglial Component, Recurrent Glioblastoma, Relapsed Glioblastoma

Small Cell Lung Cancer

Metastatic Breast Cancer

Lambert-Eaton Myasthenic Syndrome, Eaton-Lambert Myasthenic Syndrome

Colorectal Cancer

Leukaemia, Lymphocytic, Chronic

Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes, Previously Treated Myelodysplastic Syndromes, Refractory Anemia With Excess Blasts, Secondary Myelodysplastic Syndromes

Hematopoietic Neoplasm

Carcinoma, Non-Small-Cell Lung

BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Cavity Cancer

Actinic Keratosis

Melanoma

Breast Cancer

KRAS Mutated Colorectal Adenocarcinoma., Metastatic Pancreatic Adenocarcinoma, BRAF Mutated Melanoma

Acute Lymphoblastic Leukemia

Breast Cancer

Solitary Pulmonary Nodule, Multiple Pulmonary Nodules

Multiple Myeloma

Soft Tissue Sarcoma

Dose Escalation, Safety, Preliminary Efficacy, Advanced Solid Tumors, Metastatic Breast Cancer, Advanced Pancreatic Adenocarcinoma, Metastatic Colorectal Cancer, Recurrent Glioblastoma Multiforme

Recurrent Glioma

Advanced Renal Cell Carcinoma, Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma

Neuroblastoma in Remission

Non-Hodgkin's Lymphoma, Hodgkin Lymphoma, Multiple Myeloma, Chronic Myelogenous Leukemia

Melanoma

HER2 + Breast Cancer, HER2 + Gastric Cancer, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, HER2 + Breast Cancer, HER2 + Gastric Cancer, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma

Breast Cancer, Colorectal Cancer, Non-Small Cell Lung Cancer, Glioblastoma, Renal Cell Cancer

Obesity, Overweight

Prostate Cancer, Castration Resistant Prostate Cancer, Pain, Prostatic Neoplasms

Sarcoma

Breast Cancer

Cytomegalovirus Infections

Patients at Risk for Melanoma

Wegener's Granulomatosis, Microscopic Polyangiitis

Newly Diagnosed Hormone Positive Clinical Stage 1 or 2 Breast Cancer

Prostate Cancer