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  • cancer clinical trials in san pablo, CA

  • S0008: Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Melanoma (Skin)
    Comparison of Combination Chemotherapy Regimens in Treating Older Women Who Have Undergone Surgery for Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Comparison of Two Combination Chemotherapy Regimens in Treating Women With Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
    J.C. Robinson, M.D. Regional Cancer Center
    San Pablo, California 94806
    Lymphoma
    Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Lung Cancer
    Four Versus Six Cycles of Cyclophosphamide/Doxorubicin or Paclitaxel in Adjuvant Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Esophageal Cancer, Gastric Cancer
    Chemotherapy Combined With Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
    J.C. Robinson, M.D. Regional Cancer Center
    San Pablo, California 94806
    Lung Cancer
    S0221 Adjuvant Doxorubicin, Cyclophosphamide, and Paclitaxel in Treating Patients With Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Adenocarcinoma of the Colon, Stage III Colon Cancer
    Erlotinib With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Bronchoalveolar Cell Lung Cancer, Lung Cancer, Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
    Oxaliplatin, Leucovorin, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Adenocarcinoma of the Colon, Stage II Colon Cancer
    Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Primary Peritoneal Cancer, or Fallopian Tube Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Brenner Tumor, Fallopian Tube Cancer, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma, Ovarian Mucinous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Undifferentiated Adenocarcinoma, Primary Peritoneal Cavity Cancer, Stage III Ovarian Epithelial Cancer, Stage IV Ovarian Epithelial Cancer
    Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With Stage III or Stage IV Head and Neck Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Head and Neck Cancer
    Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer, Progesterone Receptor-positive Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIB Breast Cancer
    Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-Small Lung Cancer That Was Removed By Surgery
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer
    Sunitinib Malate or Sorafenib Tosylate in Treating Patients With Kidney Cancer That Was Removed By Surgery
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Clear Cell Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Stage I Renal Cell Cancer, Stage II Renal Cell Cancer, Stage III Renal Cell Cancer, Stage IV Renal Cell Cancer
    Radiation Therapy in Treating Patients With Stage II Prostate Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Prostate Cancer
    S0536: Cetuximab, Paclitaxel, Carboplatin, and Bevacizumab in Treating Patients With Advanced Non-Small Cell Lung Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Lung Cancer
    Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer, Lymphedema, Perioperative/Postoperative Complications
    Bevacizumab, Sorafenib Tosylate, and Temsirolimus in Treating Patients With Metastatic Kidney Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Cancer, Stage IV Renal Cell Cancer
    Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Fulvestrant With or Without Lapatinib in Treating Postmenopausal Women With Stage III or Stage IV Breast Cancer That is Hormone Receptor-Positive
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Recurrent Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer
    Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Stage II Squamous Cell Carcinoma of the Nasopharynx, Stage III Lymphoepithelioma of the Nasopharynx, Stage III Squamous Cell Carcinoma of the Nasopharynx, Stage IV Lymphoepithelioma of the Nasopharynx, Stage IV Squamous Cell Carcinoma of the Nasopharynx
    S0622, Dasatinib in Treating Patients With Stage IV Breast Cancer That Has Spread to the Bone
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer, Metastatic Cancer
    Doxorubicin, Cyclophosphamide, and Paclitaxel With or Without Bevacizumab in Treating Patients With Lymph Node-Positive or High-Risk, Lymph Node-Negative Breast Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Male Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
    Cisplatin or Carboplatin, and Etoposide With or Without Sunitinib Malate in Treating Patients With Extensive-Stage Small Cell Lung Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer
    Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Neurotoxicity Syndromes, Pain, Peripheral Neuropathy, Unspecified Adult Solid Tumor, Protocol Specific
    Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer
    First-Line Chemotherapy and Trastuzumab With or Without Bevacizumab in Treating Patients With Metastatic Breast Cancer That Overexpresses HER-2/NEU
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer
    Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent Squamous Cell Carcinoma of the Larynx, Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity, Recurrent Squamous Cell Carcinoma of the Nasopharynx, Recurrent Squamous Cell Carcinoma of the Oropharynx, Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity, Recurrent Verrucous Carcinoma of the Larynx, Recurrent Verrucous Carcinoma of the Oral Cavity, Salivary Gland Squamous Cell Carcinoma, Stage IV Salivary Gland Cancer, Stage IV Squamous Cell Carcinoma of the Hypopharynx, Stage IV Squamous Cell Carcinoma of the Larynx, Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage IV Squamous Cell Carcinoma of the Nasopharynx, Stage IV Squamous Cell Carcinoma of the Oropharynx, Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity, Stage IV Verrucous Carcinoma of the Larynx, Stage IV Verrucous Carcinoma of the Oral Cavity, Tongue Cancer, Untreated Metastatic Squamous Neck Cancer With Occult Primary
    Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage III or Stage IV Breast Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Recurrent Breast Cancer, Stage IIIB Breast Cancer, Stage IV Breast Cancer
    S0709: Erlotinib With or Without Carboplatin and Paclitaxel in Stage IIIB or Stage IV Non-Small Cell Lung Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Lung Cancer
    Capecitabine and Lapatinib With or Without Cixutumumab in Treating Patients With Previously Treated HER2-Positive Stage IIIB, Stage IIIC, or Stage IV Breast Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer
    Sunitinib as Maintenance Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Previously Treated With Combination Chemotherapy
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
    Pemetrexed and/or Sunitinib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
    S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, Stage II, or Stage IIIA Breast Cancer Undergoing Chemotherapy
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer, Chemotherapeutic Agent Toxicity, Fatigue, Neuropathy, Neurotoxicity
    Paclitaxel, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, or Ixabepilone With or Without Bevacizumab in Treating Patients With Stage IIIC or Stage IV Breast Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Male Breast Cancer, Recurrent Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer
    Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer
    Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed By Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Cancer, Male Breast Cancer, Progesterone Receptor-negative Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Triple-negative Breast Cancer
    Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer, Metastatic Cancer, Multiple Myeloma and Plasma Cell Neoplasm, Musculoskeletal Complications, Pain, Prostate Cancer, Urinary Complications
    S0904: Docetaxel With or Without Vandetanib in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
    S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer, Lung Cancer, Metastatic Cancer, Multiple Myeloma, Plasma Cell Neoplasm, Prostate Cancer, Unspecified Adult Solid Tumor, Protocol Specific
    S9925: Collecting and Storing Samples From Patients With Lung Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Lung Cancer
    Dinaciclib in Treating Patients With Stage IV Melanoma
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Acral Lentiginous Malignant Melanoma, Lentigo Maligna Malignant Melanoma, Mucosal Melanoma, Nodular Malignant Melanoma, Recurrent Melanoma, Stage IV Melanoma, Superficial Spreading Malignant Melanoma
    Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Distal Urethral Cancer, Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter, Proximal Urethral Cancer, Recurrent Bladder Cancer, Recurrent Prostate Cancer, Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter, Recurrent Urethral Cancer, Stage IV Bladder Cancer, Stage IV Prostate Cancer, Transitional Cell Carcinoma of the Bladder, Urethral Cancer Associated With Invasive Bladder Cancer
    Carboplatin, Paclitaxel, and Bevacizumab With or Without Everolimus in Treating Patients With Metastatic Malignant Melanoma
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Melanoma (Skin)
    Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
    Seneca Valley Virus-001 After Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Lung Cancer
    Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine, With or Without Bevacizumab, as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II, Stage III, Stage IV, or Recurrent Stage I Epithelial Ovarian Cancer or Fallopian Tube Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Ovarian Mucinous Cystadenocarcinoma, Ovarian Mucinous Cystadenoma With Proliferating Activity, Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer, Stage IA Fallopian Tube Cancer, Stage IA Ovarian Epithelial Cancer, Stage IB Fallopian Tube Cancer, Stage IB Ovarian Epithelial Cancer, Stage IC Fallopian Tube Cancer, Stage IC Ovarian Epithelial Cancer, Stage IIA Fallopian Tube Cancer, Stage IIA Ovarian Epithelial Cancer, Stage IIB Fallopian Tube Cancer, Stage IIB Ovarian Epithelial Cancer, Stage IIC Fallopian Tube Cancer, Stage IIC Ovarian Epithelial Cancer, Stage IIIA Fallopian Tube Cancer, Stage IIIA Ovarian Epithelial Cancer, Stage IIIB Fallopian Tube Cancer, Stage IIIB Ovarian Epithelial Cancer, Stage IIIC Fallopian Tube Cancer, Stage IIIC Ovarian Epithelial Cancer, Stage IV Fallopian Tube Cancer, Stage IV Ovarian Epithelial Cancer
    S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    brca1 Mutation Carrier, brca2 Mutation Carrier, Breast Cancer
    Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Kidney Cancer
    Paclitaxel and Carboplatin With or Without Bevacizumab in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma, Ovarian Mucinous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Undifferentiated Adenocarcinoma, Stage IIA Fallopian Tube Cancer, Stage IIA Ovarian Epithelial Cancer, Stage IIA Primary Peritoneal Cavity Cancer, Stage IIB Fallopian Tube Cancer, Stage IIB Ovarian Epithelial Cancer, Stage IIB Primary Peritoneal Cavity Cancer, Stage IIC Fallopian Tube Cancer, Stage IIC Ovarian Epithelial Cancer, Stage IIC Primary Peritoneal Cavity Cancer, Stage IIIA Fallopian Tube Cancer, Stage IIIA Ovarian Epithelial Cancer, Stage IIIA Primary Peritoneal Cavity Cancer, Stage IIIB Fallopian Tube Cancer, Stage IIIB Ovarian Epithelial Cancer, Stage IIIB Primary Peritoneal Cavity Cancer, Stage IIIC Fallopian Tube Cancer, Stage IIIC Ovarian Epithelial Cancer, Stage IIIC Primary Peritoneal Cavity Cancer, Stage IV Fallopian Tube Cancer, Stage IV Ovarian Epithelial Cancer, Stage IV Primary Peritoneal Cavity Cancer
    Vorinostat and Radiation Therapy Followed By Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Pontine Glioma
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Childhood Mixed Glioma, Untreated Childhood Brain Stem Glioma
    Everolimus With or Without Bevacizumab in Treating Patients With Advanced Kidney Cancer That Progressed After First-Line Therapy
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Cancer, Stage III Renal Cell Cancer, Stage IV Renal Cell Cancer
    Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Breast Cancer
    Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-positive Breast Cancer, Progesterone Receptor-negative Breast Cancer, Progesterone Receptor-positive Breast Cancer, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIC Breast Cancer
    S0927: Omega-3-Fatty Acid Supplements in Treating Muscle and Bone Pain and Stiffness in Pts W/Stage I, II, or III Breast Cancer Receiving Hormone Therapy
    Doctors Medical Center - San Pablo Campus
    San Pablo, California 94806
    Arthralgia, Breast Cancer, Pain
    Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer
    Doctors Medical Center- JC Robinson Regional Cancer Center
    San Pablo, California 94806
    Breast Cancer