Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Feasibility

Outcome Description:

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, we will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells. Markers of induced pluripotent phenotype will be utilized to assess successful reprogramming.

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

Dennis A Wigle, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic

Authority:

United States: Institutional Review Board

Study ID:

09-005334

NCT ID:

NCT01860898

Start Date:

September 2009

Completion Date:

January 2017

Related Keywords:

• Thoracic Diseases
• Respiratory Tract Diseases
• Cancer of Lung
• Cancer of the Lung
• Lung Cancer
• Lung Diseases, Obstructive
• COPD
• Pulmonary Emphysema
• Neoplasms, Lung
• Neoplasms, Pulmonary
• Pulmonary Cancer
• Pulmonary Neoplasms
• Carcinoma, Non-Small-Cell Lung
• Carcinoma, Small Cell
• lung
• cancer
• thoracic
• chest
• pulmonary
• Neoplasms
• Carcinoma
• Carcinoma, Non-Small-Cell Lung
• Emphysema
• Pulmonary Emphysema
• Lung Diseases
• Pulmonary Disease, Chronic Obstructive
• Lung Neoplasms
• Respiratory Tract Diseases
• Thoracic Diseases
• Carcinoma, Small Cell
• Lung Diseases, Obstructive