Inclusion Criteria:

- Have minimally symptomatic metastatic castration recurrent prostate cancer with bone
lesions; this patient population is defined as having failed hormone treatment;
minimally symptomatic will be defined as no need for narcotic pain medication

- Patients that have been prescribed sipuleucel-T and have not started treatment

- Must be candidates for radiation treatment to bone lesions

- Patient or legal representative must understand the investigational nature of this
study and sign an Independent Ethics Committee/Institutional Review Board approved
written informed consent form prior to receiving any study related procedure

- Have an Eastern Cooperative Oncology Group (ECOG) performance status of =< 2

Exclusion Criteria:

- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
nitrosoureas or mitomycin C) prior to entering the study or those who have not
recovered from adverse events due to agents administered more than 4 weeks earlier

- Patients who have received prior radiation of osseous lesions

- Patients who have received any prior immunotherapy

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Unwilling or unable to follow protocol requirements

- Any condition which in the investigator's opinion deems the patient an unsuitable
candidate