Inclusion Criteria:

- Histologically proven primary soft tissue sarcoma of the upper extremity (including
shoulder), lower extremity (including hip) or body trunk (excluding retroperitoneum).

- No clinical evidence of distant metastatic disease

- Evaluation by surgeon, with documentation that the tumor is resectable

- ECOG performance status 0-1

- For females of childbearing potential, a serum pregnancy test within 4 weeks prior to
registration

- Patient must practice adequate contraception

- Adequate bone marrow function

Exclusion Criteria:

- Patients with sarcoma of the head, neck, intra-abdominal or retroperitoneal region,
hand or foot

- Histopathology demonstrating rhabdomyosarcoma, extraosseous primitive neuroectodermal
tumor (PNET), soft tissue Ewing's sarcoma, osteosarcoma, Kaposi's sarcoma,
angiosarcoma, aggressive fibromatosis, dermatofibrosarcoma protuberans or
chondrosarcoma

- Clinical evidence of regional lymph node or distant metastatic disease

- Prior invasive malignancy (except non-melanomatous skin cancer or early stage
prostate cancer) unless disease free for a minimum of 3 years

- Prior radiotherapy to the potential target anatomic region would result in overlap of
radiation fields for current sarcoma

- Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to used medically acceptable forms of contraception