Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
18 Years
75 Years
Female
Breast Cancer, Vitamin D Deficiency
Trial Information
Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
Background: The role of vitamin D in breast cancer prevention is equivocal. Saudi Arabian
women are thought to be at greater risk for vitamin D deficiency due to darker skin type and
greater likelihood for reduced UVB radiation exposure. However, there is a lack of data
regarding the vitamin D status of Saudi Arabian women and how this may relate to breast
cancer risk.
Objective: The purpose of this research was to evaluate the association between circulating
concentrations of 25(OH)D and breast cancer risk in Saudi Arabian women.
Design: A case-control study was conducted among 120 breast cancer cases and 120 controls.
The study population was drawn from patients admitted to King Fahd Hospital in Jeddah, Saudi
Arabia from June to August 2009. Participants completed questionnaires on diet and medical
history and serum samples were collected from all women to measure circulating 25(OH)D
concentrations.
Inclusion Criteria:
- Invasive breast cancer (cases) or healthy women (controls),
- receiving standard medical check-ups at the women's clinic
- Female,
- between the ages of 18 and 75 years
- BMI ≤ 40 kg/m2
- residence in Saudi Arabia for more than 5 years
- absence of chronic diseases that could affect vitamin D metabolism, including renal,
hepatic, endocrine, or autoimmune disease.
Exclusion Criteria:
receiving standard medical check-ups at the women's clinic
- Male,
- less than 18 or greater than 75 years of age
- BMI > 40 kg/m2
- Not a resident of Saudi Arabia for more than 5 years
- Presence of chronic diseases that could affect vitamin D metabolism, including renal,
hepatic, endocrine, or autoimmune disease.
Type of Study:
Observational
Study Design:
Observational Model: Case Control, Time Perspective: Prospective
Outcome Measure:
serum vitamin D
Outcome Description:
assessed serum vitamin D in cases versus controls
Outcome Time Frame:
cross-sectional from May 2009-August 2009
Safety Issue:
No
Principal Investigator
Cynthia A Thomson, PhD
Investigator Role:
Study Chair
Investigator Affiliation:
University of Arizona
Authority:
United States: Institutional Review Board
Study ID:
SAVitaminD
NCT ID:
NCT01817231
Start Date:
May 2009
Completion Date:
August 2009
Related Keywords:
- Breast Cancer
- Vitamin D Deficiency
- breast cancer
- vitamin D
- 25 OH vitamin D
- Breast Neoplasms
- Vitamin D Deficiency
Name | Location |
|---|---|
| University of Arizona | Tucson, Arizona 85724 |
