Wellderly Immune Antibodies Study, a Sub-Study of Healthy Elderly Active Longevity (HEAL) Cohort (HSC# 004789)

Inclusion Criteria

INCLUSION CRITERIA

1. Age 90 and over

2. Gender: Male and Female

3. Enrolled in the Healthy Elderly (HEAL) study prior to enrollment in this sub-study

4. Eligible for Blood draw

5. Be reliable, cooperative and willing to comply with all protocol-specified
procedures.

6. Able to understand and grant informed consent

7. Be healthy or have mild medical conditions that may be associated with the normal
aging process, including:

- Hypertension, well controlled with no more than 3 medications

- Osteoporosis or Osteopenia

- Osteoarthritis

- Benign Prostatic Hypertrophy

- Cataracts, Glaucoma or Macular Degeneration

- Dyslipidemia

- Hypothyroidism

- Pre-Diabetes/Impaired Fasting Glucose (fasting blood glucose 100-126 mg/dL, if
known)

- Basal or Squamous Cell Carcinoma

Individuals will be excluded if ANY of the following conditions apply:

EXCLUSION CRITERIA

1. Less than 90 years of age

2. Currently undergoing treatment with any investigational agents or devices within 30
preceding enrollment in this study.

3. Self-reported history or current diagnosis of significant chronic conditions
including:

- Any Cancer (including polycythemia; excluding basal or squamous cell carcinoma

- Coronary Artery Disease, Myocardial Infarction

- Stroke or Transient Ischemic Attack (TIA)

- Deep Vein Thrombosis or Pulmonary Embolism

- Chronic Renal Disease or Hemodialysis

- Significant Auto-Immune or Inflammatory conditions such as Rheumatoid Arthritis,
Lupus, Crohn's Disease, etc.

- Alzheimer's or Parkinson's Disease

- Diabetes (Hemoglobin A1C > 6.5% or fasting glucose > 126 mg/dL or is treated
with insulin or oral diabetic medication

- Aortic or Cerebral Aneurysm

4. Currently taking any of the following medications on a regular basis:

- Chemotherapeutic agents (ex. Tamoxifen, Doxorubicin, Mitoxantrone, bleomycin

- Anti-platelet or anticoagulant agents, not including Aspirin (ex.
Clopidogrel/Plavix, Dipyridamole/Aggrenox/Persantine, Ticlopidine/Ticlid,
Warfarin/Coumadin, Prasugrel, etc.)

- Cholinesterase inhibitor for Alzheimer's disease (ex. Donzepril/Aricept)

- Insulin or oral diabetic medication

5. Individual has a significant medical condition which, in the investigator's opinion,
may interfere with the individual's optimal participation in the study or would
potentially confound interpretation of the individual's phenotype.