Observational - Gene Discovery in Osteosarcoma
N/A
N/A
Both
Osteosarcoma
Trial Information
Observational - Gene Discovery in Osteosarcoma
Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective:
Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study
Population Description: Samples from the COG Sampling Method: Non-Probability Sample
PRIMARY OBJECTIVES:
I. To use PET sequencing to analyze DNA from ten human primary osteosarcoma samples, along
with matched normal tissue where available.
OUTLINE:
Tissue samples are analyzed for translocations and deletions and analyzed using polymerase
chain reaction (PCR) or fluorescence in situ hybridization (FISH).
Inclusion Criteria:
- Samples from the COG tissue repository
Type of Study:
Interventional
Study Design:
Intervention Model: Single Group Assignment, Masking: Open Label
Outcome Measure:
Mapping and filtering of paired tags
Outcome Description:
Mapping of paired tags to reference genomes to identify aberrant pairs, caused by translocations, insertions, deletions and inversions.
Outcome Time Frame:
Up to 2 years
Safety Issue:
No
Principal Investigator
Richard Gorlick
Investigator Role:
Principal Investigator
Investigator Affiliation:
Children's Oncology Group
Authority:
United States: Institutional Review Board
Study ID:
AOST10B1
NCT ID:
NCT01807143
Start Date:
January 2010
Completion Date:
Related Keywords:
- Osteosarcoma
- Osteosarcoma
Name | Location |
|---|---|
| Children's Oncology Group | Arcadia, California 91006-3776 |
