Screening Protocol to Detect BRAF V600 Mutation-Positive Patients for Enrollment Into Clinical Research Studies of Vemurafenib

Inclusion Criteria:

- Histologically confirmed solid tumors (excluding melanoma and papillary thyroid
cancer) or multiple myeloma refractory to standard therapy or for which standard or
curative therapy does not exist or is not considered appropriate by the investigator

- Patients with multiple myeloma must have received at least one line of prior systemic
therapy for the treatment of multiple myeloma

Exclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status > 2

- Uncontrolled concurrent malignancy

- Active or untreated CNS metastases

- History of known carcinomatous meningitis

- Prior treatment with a BRAF or MEK inhibitor (prior sorafenib is allowed)

- Uncontrolled, severe medical illness or condition as defined in protocol MO28072