EVAULATION OF IMPLANTATION AND PREGNANCY AFTER ENDOMETRIAL INJURY VIA ENDOMETRIAL PIPELLE BIOPSY IN THE CYCLE PRIOR TO IVF: A RANDOMIZED, SINGLE-BLINDED, CONTROLLED TRIAL.

Trial Information

EVAULATION OF IMPLANTATION AND PREGNANCY AFTER ENDOMETRIAL INJURY VIA ENDOMETRIAL PIPELLE BIOPSY IN THE CYCLE PRIOR TO IVF: A RANDOMIZED, SINGLE-BLINDED, CONTROLLED TRIAL.

Despite advances in assisted reproductive technologies; implantation failure in patients
undergoing in-vitro fertilization (IVF) is frequent. Unfortunately, few treatments exist
except for the use of a gestational carrier. There have been a number of recent clinical
studies demonstrating that local injury to the endometrium results in improved clinical
pregnancy outcomes for patients with a history of implantation failure. However, not all
studies have shown a beneficial effect, and those demonstrating benefit have been limited by
small sample sizes, and considerable heterogeneity in the procedures and populations
evaluated. A recent meta-analysis synthesized the available data concluded that a large,
prospective, well-designed randomized trial is desperately needed to definitively assess
this new possible treatment. If these preliminary findings from previous trials are
confirmed, this practice could be applied in the clinical setting to help patients suffering
from repeated implantation failures.