Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

Inclusion Criteria:

- Male gender

- Age ≥35

- Current smoker of at least 10 cigarettes per day with history of ≥10 pack-years (py)

- Former smoker, quit no more than 15 years ago with a history of at least 25 py

- Ability to comply with the design of the study

- Capacity to freeze urine sample at participant's residence if this participant
desires to store the urine specimens in this manner

- Baseline urine PGE-M > 13 ng/mg creatinine

- Serum thromboxane > 150 μg/L

Exclusion Criteria:

- History of aspirin use 1-14 days prior to screening

- NSAID (ibuprofen, naprosyn, meloxicam, etc) use 1-7 days prior to screening

- Inhaled glucocorticoid use 1-7 days prior to screening

- Systemic glucocorticoid use 1-14 days prior to screening

- History of peptic ulcer disease

- Current or recent clinically significant bleeding

- Allergy, intolerance or contraindication to aspirin or NSAID use

- Thrombocytopenia (platelet count < 100,000) in 30 days prior to screening visit

- Severe hepatic insufficiency

- GFR < 30 mL/min/1.73 m2 in 30 days prior to screening visit

- History of aspirin or celecoxib allergy

- Elevated INR (>1.5) in 30 days prior to screening visit

- Current diagnosis of malignancy or history of non-skin malignancy in last 5 years

- Current use of systemic anticoagulants (e.g., warfarin (Coumadin), enoxaparin
(Lovenox), Fondaparinux (Arixtra), dabigatran (Pradaxa))

- Diagnosis of COPD

- Intake of > 250 mg of fish oil supplementation daily