Detection of Early Lung Cancer Among Military Personnel Study 1 (DECAMP-1): Diagnosis and Surveillance of Indeterminate Pulmonary Nodules
The Detection of Early lung Cancer Among Military Personnel (DECAMP) consortium is a
multidisciplinary and translational research program that includes 7 Veterans Administration
Hospitals (VAH), the 4 designated Military Treatment Facilities (MTF) and one academic
hospital as clinical study sites, several molecular biomarker laboratories, along with
Biostatics, Bioinformatics, Pathology and Biorepository cores. The DECAMP Coordinating
Center will facilitate rapid selection, design and execution of clinical studies within this
multi-institutional consortium. The goal will be accomplished by recruiting 500 smokers with
indeterminate pulmonary nodules (0.7cm-2cm) on chest CT who will undergo fiberoptic
bronchoscopy and will be followed for 2 years until a final diagnosis is made. The
diagnostic performance of four previously established lung cancer biomarkers in this cohort
will be validated; 1) a gene-expression biomarker measured in bronchial airway brushings; 2)
a proteomic signatures measured in bronchial airway biopsies; 3) a proteomic signature
measured in serum; and 4) a signature of serum cytokines. The added value of the molecular
markers to clinical and imaging markers routinely used in the diagnostic work up of these
patients and develop an integrated model (i.e. clinical, imaging & molecular markers) that
results in the most robust diagnostic predictor will be evaluated.
Observational
Observational Model: Case Control, Time Perspective: Prospective
Lung Cancer
Subjects will be identified as Lung Cancer or no Lung Cancer (through diagnosis) within the 2 year followup period.
2 years
No
Avrum Spira, MD
Principal Investigator
Boston University
United States: Department of Defense: HRPO: Dr. Julie Wilberding
DECAMP-1
NCT01785342
January 2013
September 2016
Name | Location |
---|---|
Walter Reed National Military Medical Center | Bethesda, Maryland 20889 |
Naval Medical Center San Diego | San Diego, California 92134 |
Naval Medical Center Portsmouth | Portsmouth, Virginia 23708 |
Veterans Research Foundation of Pittsburgh | Pittsburgh, Pennsylvania 15240 |
San Antonio Military Medical Center | Fort Sam Houston, Texas 78234 |
Regents of the University of California LA (Los Angeles VA Healthcare System) | Los Angeles, California |
Denver Research Institute | Denver, Colorado |
Boston VA Research Institute, Inc | Boston, Massachusetts |
Health Research Inc. Roswell Park Division | Buffalo, New York |
Trustees of University of Pennsylvania (Philadelphia VA Medical Center) | Philadelphi, Pennsylvania |
Middle Tennessee Research Institute (Vanderbilt University) | Nashville, Tennessee |
Dallas VA Research Corporation | Dallas, Texas |