Inclusion Criteria:

- Patients must have a histologically confirmed, unresectable pancreatic adenocarcinoma

- Patients must have already received or refused 1st-line treatment

- Measurable disease will be required; biopsiable disease will be required in the
expansion cohort in which biopsies will be conducted

- Eastern Cooperative Oncology Group (ECOG) performance status =< 1

- Life expectancy of greater than 16 weeks

- Leukocytes >= 3,000/mcL

- Absolute neutrophil count >= 1,500/mcL

- Platelets >= 100,000/mcL

- Total bilirubin =< 1.5 institutional upper limit of normal (IULN)

- Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT)(serum glutamate pyruvate transaminase [SGPT])
=<2.5 X IULN if no liver metastasis or =< 5 X IULN if liver metastases are present

- Creatinine within normal institutional limits OR creatinine clearance >= 60
mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

- The effects of MK-2206 and dinaciclib on the developing human fetus are unknown; for
this reason, women of child-bearing potential and men must agree to use adequate
contraception (hormonal or barrier method of birth control; abstinence) prior to
study entry and for the duration of study participation; should a woman become
pregnant or suspect she is pregnant while she or her partner is participating in this
study, she should inform her treating physician immediately; men treated or enrolled
on this protocol must also agree to use adequate contraception prior to the study,
for the duration of study participation, and 4 months after completion of MK-2206 and
dinaciclib administration

- Patients must be able to swallow whole tablets (for MK-2206); nasogastric or G tube
administration is not allowed; tablets must not be crushed or chewed

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
nitrosoureas or mitomycin C) prior to entering the study or those who have not
recovered from adverse events due to agents administered more than 4 weeks earlier

- Patients who are receiving any other investigational agents

- Patients with known brain metastases should be excluded from this clinical trial
because of their poor prognosis and because they often develop progressive neurologic
dysfunction that would confound the evaluation of neurologic and other adverse events

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to dinaciclib or to MK-2206

- Patients receiving any medications or substances that are strong inhibitors/
inducers, sensitive substrates, or substrates with a narrow therapeutic index of
CYP3A4 or P-gp are ineligible; caution should be exercised when dosing dinaciclib
and/or MK-2206 concurrently with CYP3A4 or P-gp substrates, inhibitors/inducers; if
subjects are taken off a forbidden medicine, a one-week washout is required for
inhibitors and two weeks for inducers; subjects on Coumadin are eligible but more
frequent monitoring of the international normalized ratio (INR) (weekly during the
first cycle, then at least each cycle thereafter) is recommended; as part of the
enrollment/informed consent procedures, the patient will be counseled on the risk of
interactions with other agents, and what to do if new medications need to be
prescribed or if the patient is considering a new over-the-counter medicine or herbal
product

- Preclinical studies demonstrated the potential of MK-2206 for induction of
hyperglycemia in all preclinical species tested; patients with diabetes or in risk
for hyperglycemia should not be excluded from trials with MK-2206, but the
hyperglycemia should be well controlled before the patient enters the trial
(glycosylated hemoglobin [Hba1c] < 7.5)

- Concurrent medications associated with a risk of corrected QT (QTc) prolongation
and/or Torsades de Pointes are not allowed; those medications listed as reported but
lacking substantial evidence for causing QTc prolongation and Torsades de Pointes
will be allowed, although if an alternative medication can be substituted, that would
be preferable; for this study, a baseline electrocardiogram (EKG) will be performed
and will be repeated during cycle 1 and then every 3 cycles while on treatment;
patients with current evidence of significant cardiovascular disease (New York Heart
Association Class III or IV cardiac disease), symptomatic congestive heart failure,
dilated/hypertrophic or restrictive cardiomyopathy, myocardial infarction (within the
past 6 months), unstable angina, unstable arrhythmia or a need for anti-arrhythmic
therapy (use of medications for rate control for atrial fibrillation is allowed such
as calcium channel blockers and beta-blockers, if stable medication for at least last
month prior to initiation of MK-2206 treatment and medication not listed as causing
Torsades de Pointes), or evidence of acute ischemia on electrocardiogram (ECG);
marked baseline prolongation of QT/QTc interval, e.g., repeated demonstration of a
QTc interval > 450 msec*; Long QT Syndrome; the required use of concomitant
medication that may cause Torsades de Pointes or may cause a significant prolongation
of the QTc

- Note: Due to difficulties assessing QTc in patients with heart block, they may
be eligible if deemed safe by a cardiologist

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant women are excluded from this study because MK-2206 and dinaciclib are agents
with the potential for teratogenic or abortifacient effects; because there is an
unknown but potential risk for adverse events in nursing infants secondary to
treatment of the mother with MK-2206 and/or dinaciclib breastfeeding should be
discontinued if the mother is treated with MK-2206 and/or dinaciclib

- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral
therapy are ineligible because of the potential for pharmacokinetic interactions with
MK-2206 and dinaciclib; in addition, these patients are at increased risk of lethal
infections when treated with marrow-suppressive therapy; appropriate studies will be
undertaken in patients receiving combination antiretroviral therapy when indicated

- Clinically significant ascites