Inclusion Criteria:

- Female gender

- Age 18 years or older

- Any ethnicity

- Are undergoing neoadjuvant therapy for locally advanced breast cancer with either
chemotherapy or hormonal therapy

- Is able to provide informed consent.

Exclusion Criteria:

- Pregnancy

- Lactation

- Women who are unable or unwilling to understand or to provide informed consent

- Women with physical limitations that may prohibit resting prone on the exam table,
such as, but not limited to: frozen shoulder, recent heart surgery, pace maker.

- Women who are unable to tolerate study constraints.

- Women who have received radiation treatments to the thorax for malignant and
nonmalignant conditions, such as (but not limited to):

- Treatment for enlarged thymus gland as an infant

- Irradiation for benign breast conditions, including breast inflammation after giving
birth

- Treatment for Hodgkin's disease

- Women who have participated in a prior breast clinical trial that gave additional
radiation dose, such as an additional mammogram.

- Women who have received large numbers of diagnostic x-ray examinations for monitoring
of disease such as (but not limited to):

- Tuberculosis

- Severe scoliosis