Inclusion Criteria:
- ≥ 18 years of age
- Biopsy-proven, previously untreated squamous cell carcinoma, adenosquamous carcinoma,
or adenocarcinoma of the uterine cervix
- Clinically visible lesion at least FIGO stage Ib or AJCC 7th edition T1b
- Scheduled to undergo standard of care PET/CT for baseline assessment of disease
- Anticipated to be eligible for curative intent therapy (surgery of chemoradiation
therapy) as determined by the patient's primary oncologist
- If female of child-bearing potential, negative serum or urine pregnancy test ≤ 7 dats
prior to first PET/MRI
- Informed consent reviewed and signed
Exclusion Criteria:
- History of sever reaction to contrast-enhanced CT scan
- Inability to tolerate MRI (e.g., inability to lie flat > 1 hour)
- Presence of pacemaker, intracranial aneurysm clip, bladder stimulator, cochlear
implant or metal near eyes
- Poorly controlled diabetes mellitus
- Creatinine > 1.4 mg/dL or GFR < 30 mL/min
- Body Mass Index (BMI) > 35
- Active vaginal bleeding requiring packing and emergent radiation therapy
- Pregnant or lactating female
- History of a prior malignancy within past 5 years, unless disease free for ≥ 3 years
- Substance abuse, medical, psychological, or social conditions that may interfere with
study participation