Investigation of the Magnitude of Uptake, Retention, and Spatial Distribution Pattern of 18F-Choline in Comparison With MRI and Histology Obtained From Prostate Cancer Biopsies

Inclusion Criteria:

- Males 40 years of age or older scheduled for prostate biopsy (for known or suspected
prostate cancer) followed by planned prostatectomy (population group A)

- Males 40 years of age or older with known (biopsy‐confirmed) primary adenocarcinoma
of the prostate undergoing active surveillance scheduled for prostate biopsy
(population group B)

Exclusion Criteria:

- Androgen ablation (hormone treatment) within the last 3 months

- Prostate biopsy within 6 weeks prior to PET or MRI imaging

- Active inflammatory bowel disease within the last 6 months

- Acute prostatitis within the last 6 months

- A non‐urologic bacterial infection requiring active treatment with antibiotics

- Active other malignancy (except basal cell or squamous cell skin cancer) within the
last 2 years

- Previous radiation treatment of the pelvis

- Symptomatic distal rectal stenosis

- Known hypersensitivity to glucagon

- Pheochromocytoma, insulinoma or galactosemia

- Insulin‐dependent diabetes