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Patient Derived Breast Cancer Xenografts


N/A
18 Years
N/A
Not Enrolling
Female
Metastatic Breast Cancer

Thank you

Trial Information

Patient Derived Breast Cancer Xenografts

Inclusion Criteria


- Histologic documentation of invasive breast cancer by core needle or incisional
biopsy

- Cytologic documentation of metastatic disease within a body cavity, for subjects
having therapeutic removal of pleural or ascitic fluid.

- Intent to perform surgical resection of the primary tumor, or therapeutic removal of
pleural or ascitic fluid.

- Women > age 18.

- For subjects having a surgical resection of the primary tumor, the tumor must have a
clinical size of 1 cm or greater, and must not have a lobular histology on the
diagnostic biopsy.

- Ability to give signed informed consent

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Successful Engraftment

Outcome Description:

Thirty-five patients with breast cancer will be recruited. We anticipate that 10-30% will have successful engraftment of tumor tissue. The achievement of five successful xenografts would justify additional study.

Outcome Time Frame:

2 years

Safety Issue:

No

Principal Investigator

Gary Schwartz, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center

Authority:

United States: Institutional Review Board

Study ID:

D12168

NCT ID:

NCT01750164

Start Date:

October 2012

Completion Date:

Related Keywords:

  • Metastatic Breast Cancer
  • Breast Cancer
  • Breast Neoplasms

Name

Location
Dartmouth Hitchcock Medical Center Lebanon, New Hampshire  03756