Inclusion Criteria:

- Patients with histologically confirmed WHO Grade IV primary malignant glioma
(glioblastoma or gliosarcoma);

- Patients ≥ 18 years of age;

- An interval of at least 2 weeks, but not ≥ 8 weeks between prior surgical procedure
and initiation of treatment;

- Karnofsky Performance Status (KPS) ≥ 60%

- Laboratory Values:

- Platelet Count ≥ 125,000 cells/µL

- Absolute neutrophil count (ANC) ≥ 1,500 cells/µL

- Adequate renal function indicated by all of the following:

- Serum creatinine ≤ 1.25 x upper limit of normal (ULN) or calculated
creatinine clearance ≥ 50 ml/min

- Urine dipstick for proteinuria < 2+ unless a 24-hour urine protein < 1 g of
protein is demonstrated

- internationalized normalized ratio (INR) ≤ 1.5 and activated partial
thromboplastin time (aPTT) ≤ 1.5 x upper limit of normal (ULN) within 7 days
prior to first study treatment for patients not receiving anti-coagulation. The
use of full-dose oral or parenteral anticoagulants is permitted as long as the
INR or aPTT is within therapeutic limits (according to the medical standard of
the enrolling institution) and the patient has been on a stable dose of
anticoagulants for at least two weeks prior to the first study treatment.

- Patients will sign an Institutional Review Board-approved informed consent form.

- Female patients must not be pregnant or breast-feeding. Female patients of
childbearing potential (defined as < 2 years after last menstruation or not
surgically sterile) must use a highly effective contraceptive method (allowed methods
of birth control, [i.e. with a failure rate of < 1% per year] are implants,
injectables, combined oral contraceptives, intra-uterine device [Intrauterine Device
(IUD); only hormonal], sexual abstinence or vasectomized partner) during the trial
and for a period of > 6 months following the last administration of trial drug(s).
Female patients with an intact uterus (unless amenorrhea for the last 24 months) must
have a negative serum pregnancy test within 7 days prior to first study treatment.

- Fertile male patients must agree to use a highly effective contraceptive method
(allowed methods of birth control [i.e. with a failure rate of < 1% per year] include
a female partner using implants, injectables, combined oral contraceptives,
Intrauterine Device (IUDs) [only hormonal], sexual abstinence or prior vasectomy)
during the trial and for a period of > 6 months following the last administration of
trial drugs.

Exclusion Criteria:

- Any prior treatment for any grade glioma, including, but not limited to gliadel
wafers, immunotherapy (including vaccine therapy), radiation therapy or chemotherapy,
irrespective of grade of the tumor (NOTE: 5-aminolevulinic acid (ALA)-mediated
photodynamic therapy administered prior to surgery to aid in optimal surgical
resection is not considered a chemotherapy agent.);

- Co-medication that may interfere with study results; e.g. immuno-suppressive agents
other than corticosteroids;

- Active infection requiring intravenous antibiotics;

- Prior or current treatment with bevacizumab or other anti-angiogenic treatment (i.e.
anti-vascular endothelial growth factor (VEGF) or vascular endothelial growth factor
receptor (VEGFR) therapies or tyrosine kinase inhibitors) for any condition;

- Treatment with any other investigational agent within 28 days or 2 investigational
agent half-lives (whichever is longer) prior to first study treatment;

- Prior, unrelated malignancy requiring current active treatment with the exception of
cervical carcinoma in situ and adequately treated basal cell or squamous cell
carcinoma of the skin;

- Evidence of > Grade 1 central nervous system (CNS) hemorrhage on post-operative MRI
scan.

Bevacizumab-Specific Exclusion Criteria:

- Inadequately controlled hypertension (defined as systolic blood pressure > 150 mmHg
and/or diastolic blood pressure > 100 mmHg) within 28 days of first study treatment;

- Prior history of hypertensive crisis, hypertensive encephalopathy, reverse posterior
leukoencephalopathy syndrome (RPLS);

- Prior history of gastrointestinal perforation or abscess;

- Clinically significant (i.e. active) cardiovascular disease, for example
cerebrovascular accidents ≤ 6 months prior to study enrollment, myocardial infarction
≤ 6 months prior to study enrollment, unstable angina, New York Heart Association
(NYHA) Grade II or greater congestive heart failure (CHF), or serious cardiac
arrhythmia uncontrolled by medication or potentially interfering with protocol
treatment;

- History or evidence upon physical/neurological examination of central nervous system
disease (e.g. seizures) unrelated to cancer unless adequately controlled by
medication or potentially interfering with protocol treatment;

- Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or
recent arterial thrombosis) within 6 months prior to start of study treatment. Any
previous venous thromboembolism > NCI common toxicity criteria adverse event (CTCAE)
Grade 3;

- History of pulmonary hemorrhage/hemoptysis ≥ grade 2 (defined as ≥ 2.5 mL bright red
blood per episode) within 1 month of first study treatment;

- History or evidence of inherited bleeding diathesis or significant coagulopathy at
risk of bleeding (i.e. in the absence of therapeutic anticoagulation);

- Current or recent (within 10 days of study enrollment) use of aspirin (>325 mg/day),
clopidogrel (>75 mg/day) or equivalent. Prophylactic use of anticoagulants is
allowed;

- Surgical procedure (including open biopsy, surgical resection, wound revision, or any
other major surgery involving entry into a body cavity) or significant traumatic
injury within 28 days prior to first study treatment, or anticipation of need for
major surgical procedure during the course of the study;

- Minor surgical procedure, e.g. stereotactic biopsy, within 7 days of first study
treatment; placement of a vascular access device, within 2 days of first study
treatment;

- History of intracranial abscess within 6 months prior to first study treatment;

- History of active gastrointestinal bleeding within 6 months prior to first study
treatment;

- Serious, non-healing wound, active ulcer, or untreated bone fracture;

- Known hypersensitivity to any component of bevacizumab or any of the study drugs;