Optimizing Fertility Treatment in Women With Polycystic Ovary Syndrome (PCOS) Using the Clomiphene Citrate Fast-Track Protocol: a Randomized Controlled Trial

Inclusion Criteria

Inclusion

- Women ages 18 - 35, desiring pregnancy

- Established diagnosis of PCOS confirmed by the Rotterdam criteria

- Oligo or anovulatory, with menstrual cycles > 35 days apart or less than 9 menstrual
cycles per year

- Normal vaginal ultrasound with endometrial stripe < 12mm

- Normal thyroid stimulating hormone (TSH) within past one year

- Normal prolactin (PRL) within past one year

- For women with previous successful Clomid treatment, a washout period of at least 6
months is required

- Negative beta hcg within past one month

- Negative progesterone within past one month

Exclusion

- BMI > 40

- Regular menstrual cycles occurring less than 35 days apart

- Evidence of other infertility factors such as endometriosis, tubal factor or male
infertility

- Prior unsuccessful Clomid ovulation cycles

- Abnormal vaginal ultrasound findings such as endometrial polyps, submucous myomas,
synechiae

- Uterine anomaly such as unicornuate or bicornuate uterus

- Presence of hydrosalpinx

- Evidence of active endocrinopathy

- Abnormal TSH

- Abnormal PRL

- Partner with abnormal semen analysis (count < 15 million sperm /ml)