Optimizing Fertility Treatment in Women With Polycystic Ovary Syndrome (PCOS) Using the Clomiphene Citrate Fast-Track Protocol: a Randomized Controlled Trial
Inclusion Criteria
Inclusion
- Women ages 18 - 35, desiring pregnancy
- Established diagnosis of PCOS confirmed by the Rotterdam criteria
- Oligo or anovulatory, with menstrual cycles > 35 days apart or less than 9 menstrual
cycles per year
- Normal vaginal ultrasound with endometrial stripe < 12mm
- Normal thyroid stimulating hormone (TSH) within past one year
- Normal prolactin (PRL) within past one year
- For women with previous successful Clomid treatment, a washout period of at least 6
months is required
- Negative beta hcg within past one month
- Negative progesterone within past one month
Exclusion
- BMI > 40
- Regular menstrual cycles occurring less than 35 days apart
- Evidence of other infertility factors such as endometriosis, tubal factor or male
infertility
- Prior unsuccessful Clomid ovulation cycles
- Abnormal vaginal ultrasound findings such as endometrial polyps, submucous myomas,
synechiae
- Uterine anomaly such as unicornuate or bicornuate uterus
- Presence of hydrosalpinx
- Evidence of active endocrinopathy
- Abnormal TSH
- Abnormal PRL
- Partner with abnormal semen analysis (count < 15 million sperm /ml)