Trial Information

The Effect of Coffee Consumption on the Intestinal Absorption of Levothyroxine Thyroid Hormone Replacement in Patients With Thyroid Carcinoma

Previous studies have suggested that taking thyroid replacement therapy with coffee
potentially hinders its absorption. We already know that food especially a fiber-rich diet,
cholestyramine resin, aluminum containing antacids, activated charcoal, and certain herbal
remedies among others interfere with the ability to absorb thyroid medicine. These findings
have prompted providers to advise patients to take their levothyroxine on an empty stomach
in the morning. However, many patients take their thyroid medicine with their morning cup of
coffee prior to eating breakfast. A small study has shown that Italian espresso coffee can
decrease the absorption of levothyroxine, but the effect of American style coffee is not
known. Given that the intestinal absorption of levothyroxine can be hindered by multiple
substances and coffee is the most commonly consumed beverage worldwide, it is important to
investigate what effect coffee may have on thyroid hormone absorption and thyroid function
tests.

Using methods similar to those used in previous studies, this study will measure thyroid
function tests in approximately 10-20 subjects (18-60 years of age) over a 6 hour period of
time after taking their thyroid medication with the specified study beverage for a 6 week
period. Subjects will be randomized to water, black coffee, coffee with milk, and black tea
as four specified study beverages, with water serving as the control beverage. Each subject
will be recruited to participate with each study beverage for a 6 week period of time in a
total of four consecutive 6 week periods. Blood draws will occur at the end of each 6 week
period on test days 1, 2, 3, and 4. The coffee will represent the most common household
coffee brand, Folgers. Thyroid function tests with each beverage will be compared to thyroid
function tests with water to determine if thyroid medication absorption is impaired by
coffee, coffee with milk, or tea.

This study will help determine the safest and most efficacious way for adults to take their
thyroid medication and will guide medical practitioners in how to counsel their patients
when they prescribe thyroid replacement therapy.