Pancreatic Juice Diagnosis From Duodenum

Trial Information

Pancreatic Juice Diagnosis From Duodenum

Pancreatic cancer (PC) is the most lethal of all major cancers with a five year survival
rate of 5 %. While stage I and II tumors leads to an improvement in survival, almost all
PCs are currently diagnosed at more advanced non-resectable stages since minimally invasive
technique which is capable of screening early-stage PC does not exist. Serum CA19-9 is not
recommended as a screening technique because of its low sensitivity and specificity. Imaging
modalities such as MRI, CT, EUS and ERCP are more accurate but are not appropriate screening
tools due to their high cost, discomfort and complications. Therefore, there is a strong
demand for a screening tool with high sensitivity and specificity which is highly acceptable
for the patient.

The investigators would like to standardize the detection method of pancreatic cancer that
uses the duodenal juice as an optional endoscopic diagnosis. It's a very useful chance to
collect pancreatic juice from duodenum, it is called "duodenal juice" ,if we collect them
without additional invasion. The investigators would like to collect duodenal juice during
undergoing upper gastrointestinal endoscopy and analyze the pancreatic tumor markers in
duodenal juice. A definite diagnosis of the patient is made with histology, cytology or
imaging diagnosis and the result of each definite diagnosis is correlated to the each marker
analyzing result of duodenal juice. Therefore this study can be positioned as a feasibility
study to confirm clinical performance.