Alternative Approaches for Nausea Control

Inclusion Criteria:

- Be female.

- Have a diagnosis of breast cancer, any stage.

- Be chemotherapy naïve and about to begin her first course of chemotherapy.

- Be scheduled to receive one of the following four common chemotherapy regimens with
the specified antiemetic regimen. They are:

1. Chemotherapy regimen: Doxorubicin/cyclophosphamide. Antiemetic regimen:
Aprepitant + palonosetron + dexamethasone on Day 1 and aprepitant +
dexamethasone on Days 2 & 3.

2. Chemotherapy regimen: Doxorubicin/cyclophosphamide/docetaxel. Antiemetic
regimen: Aprepitant + palonosetron + dexamethasone on Day 1 and aprepitant +
dexamethasone on Days 2 & 3.

3. Chemotherapy regimen: Docetaxel/carboplatin. Antiemetic regimen: Palonosetron on
Day 1 + dexamethasone on Days 1, 2, & 3.

4. Chemotherapy regimen: Docetaxel/cyclophosphamide. Antiemetic regimen:
Palonosetron on Day 1 + dexamethasone on Days 1, 2, & 3.

Note: Fosaprepitant will be allowed in place of aprepitant, and either granisetron or
ondansetron, on one or more days, will be allowed in place of palonosetron.

- Have a response of > 3 or greater on a question assessing expected nausea as
assessed on a 5-point Likert-scale anchored at one end by 1 = "I am certain I WILL
NOT have this," and at the other end by 5 = "I am certain I WILL have this."

- Be able to read English (since the assessment materials are in printed format).

- Be 18 years of age or older and give written informed consent.

Exclusion Criteria:

- Have clinical evidence of lymphedema, current bowel obstruction, or symptomatic brain
metastases, as determined by their treating oncologist.

- Be receiving concurrent radiotherapy or interferon.