A Study of HSP90 Inhibitor AT13387 Alone or in Combination With Abiraterone Acetate in the Treatment of Castration-Resistant Prostate Cancer (CRPC) no Longer Responding to Abiraterone
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Part A: Safety and tolerability of the combination of AT13387 and abiraterone and to select the most promising treatment regimen in CRPC patients who are no longer responding to treatment with abiraterone alone.
Number of patients with adverse events Change in prostate specific antigen measurement and circulating tumor cell count every 4 weeks Change in tumor measurements by RECIST 1.1 every 12 weeks
12 months
Yes
Johann De Bono, MD
Principal Investigator
Royal Marsden Foundation Trust Institute of Cancer Research
United States: Food and Drug Administration
AT13387-04
NCT01685268
September 2012
January 2015
Name | Location |
---|---|
Memorial Sloan Kettering Cancer Center | New York, New York 10021 |
Roswell Park Cancer Institute | Buffalo, New York 14263 |
Washington University School of Medicine | Saint Louis, Missouri 63110 |
Fox Chase Cancer Center | Philadelphia, Pennsylvania 19111 |
University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
Southern Illinois University School of Medicine | Springfield, Illinois 62794-9658 |
Comprehensive Cancer Centers of Nevada | Las Vegas, Nevada 89109 |
Moores UCSD Cancer Center | La Jolla, California 92093-0658 |
University of Pittsburgh Medical Center | Pittsburgh, Pennsylvania 15213 |
Stanford Cancer Center | Stanford, California 94305-5824 |
SUNY Upstate Medical University | Syracuse, New York 13210 |
Holy Cross Hospital | Fort Lauderdale, Florida 33308 |
Cleveland Clinic | Cleveland, Ohio 44195 |
Lakeland Regional Cancer Center | Lakeland, Florida 33805 |
University of Maryland, Greenebaum Cancer Center | Baltimore, Maryland 21201 |
Northwest Medical Specialists, PLLC | Tacoma, Washington 98405 |
The West Clinic | Memphis, Tennessee 38120 |
Center for Cancer & Blood Disorders | Bethesda, Maryland 20817 |
Columbia University Medical Center | New York, New York 10032 |
NYU Clinical Cancer Center | New York, New York 10016 |
Clinical Research Alliance, Inc. | Lake Success, New York 11042 |
University of California, Los Angeles Institute of Urologic Oncology | Los Angeles, California 90024 |
Florida Cancer Specialists-Fort Myers | Fort Myers, Florida 33916 |
MD Anderson-Orlando-Orlando Health | Orlando, Florida 32806 |