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Discovery and Validation of Proteogenomic Biomarker Panels in a Prospective Serial Blood & Urine Monitoring Study of Liver Transplant Recipients


N/A
18 Years
N/A
Not Enrolling
Both
Proteogenomic Monitoring in Liver Transplant Recipients

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Trial Information

Discovery and Validation of Proteogenomic Biomarker Panels in a Prospective Serial Blood & Urine Monitoring Study of Liver Transplant Recipients


Inclusion Criteria:



- Subjects undergoing primary deceased-donor or living donor liver transplantation.

- Subject must be able to understand and provide informed consent.

Exclusion Criteria:

- Need for combined organ transplantation

- Previous solid organ and/or islet cell transplantation

- Infection with HIV

- Allergy to Iodine

- Inability or unwillingness of a participant to comply with study protocol

- Any condition that, in the opinion of the investigator, would interfere with the
participant's ability to comply with study requirements

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Acute Rejection

Outcome Description:

The primary endpoint is the incidence of biopsy proven AR at 3, 12 and 24 months after LT.

Outcome Time Frame:

3 months after liver transplant

Safety Issue:

Yes

Principal Investigator

Josh Levitsky, MD, MS

Investigator Role:

Study Chair

Investigator Affiliation:

Northwestern Univ.

Authority:

United States: Federal Government

Study ID:

DAIT CTOT-14

NCT ID:

NCT01672164

Start Date:

August 2012

Completion Date:

August 2015

Related Keywords:

  • Proteogenomic Monitoring in Liver Transplant Recipients
  • liver transplantation

Name

Location
Cleveland Clinic Foundation Cleveland, Ohio  44195
Medical University of South Carolina Charleston, South Carolina  29425-0721
Baylor University Medical Center Dallas, Texas  75246
Mayo Clinic Scottsdale, Arizona  
Northwestern University, Feinberg School of Medicine Chicago, Illinois  60611
Scripps Center for Organ and Cell Transplantation La Jolla, California  92037