Inclusion Criteria:

- Confirmed diagnosis of CD30+EBV+DLBCLE (EDLBCLE). Diagnosis will be based on
identification of diffuse large cell lymphoma (DLBCL) in biopsy specimens
characterized by positivity in the malignant cell population of 2 principal markers:

- CD30 by immunohistochemistry (IHC) and

- Epstein-Barr virus (EBV) by EBER in situ hybridization (ISH)

- Histology slides and pathology material must be available at the site for each
patient before enrollment in order to be sent to the Leading Institution of the study
for central pathology review and pharmacodynamic studies.

- Patients must have progressive, relapsed or refractory disease after:

- At least one prior systemic anti-lymphoma regimen (chemotherapy or
immunotherapy)

- Relapsed or failed autologous or allogeneic stem cell transplant.

- Understand and voluntarily sign an Institutional Review Board (IRB) approved informed
consent form

- Must have at least one site of disease (index lesion) measurable in two dimensions by
computed tomography (CT)

- At least 4 weeks since the last chemotherapy, radiation therapy, immunotherapy or any
investigational non-immunotherapy products with clinical evidence of recovery from
any toxicity associated with such treatment

- Must meet the following criteria within 4 days before the first dose of study drug:

- Neutrophils ≥1,000/ul

- Hemoglobin ≥ 8 g/dL

- Platelets≥ 50.0x10^9 /L

- Total bilirubin ≤ 1.5 x upper normal limit, or ≤ 5 x upper normal limit if
documented hepatic involvement with lymphoma or history of Gilbert's Syndrome

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x upper
normal limit (≤ 5 x upper normal limit if documented hepatic involvement with
lymphoma)

- Calculated creatinine clearance ≥ 40 mL/min/1.73 m^2 based on Cockcroft and
Gault method

- Prothrombin time (PT) or international normalization ratio (INR), and activated
partial thromboplastin time (APTT) ≤ 1.5 x upper limit of normal (ULN) unless
patient is receiving anticoagulants. If patient is on anticoagulation therapy,
levels should be within therapeutic range.

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- Negative pregnancy test for women of childbearing potential

- Recovered (≤ Grade 1 toxicity) from the reversible effects of prior antineoplastic
therapy

Exclusion Criteria:

- Any of the following cardiovascular conditions or values within 6 months before the
first dose of study drug: Myocardial infarction and the New York Heart Association
(NYHA) Class III or IV heart failure.

- History of another primary malignancy not in remission for at least 3 years; except
adequately treated patients with completely resected in situ carcinoma, such as
nonmelanoma skin cancer and cervical carcinoma in situ on biopsy or a squamous
intraepithelial lesion on Pap smear

- Known active cerebral/meningeal involvement with lymphoma. Asymptomatic patients with
previously treated and resolved central nervous system (CNS) lymphoma involvement are
permitted.

- Prior administration of Brentuximab vedotin

- Corticosteroid monotherapy for lymphoma within 2 weeks of the first dose of study
drug

- Radioimmunotherapy administration within 8 weeks before the first dose of study drug

- Any serious underlying medical condition that, in the opinion of the investigator or
medical monitor, would impair the ability to receive or tolerate the planned
treatment

- Known hypersensitivity to recombinant proteins, or any component contained in the
drug formulation

- Female patients who are lactating or have a positive serum pregnancy test during the
screening period or a positive urine pregnancy test on Day 1 before first dose of
study drug