Randomized Phase II Clinical Trial of AZD6244 Hydrogen Sulfate (NSC-748727) and MK-2206 (NSC-749607) vs mFOLFOX in Patients With Metastatic Pancreatic Cancer After Prior Chemotherapy
PRIMARY OBJECTIVES:
I. To assess overall survival in patients with metastatic pancreatic cancer treated with the
combination of AZD6244 hydrogen sulfate and MK-2206 compared to those treated with mFOLFOX.
II. To assess progression free survival (PFS) in patients with metastatic pancreatic cancer
treated with the combination of AZD6244 hydrogen sulfate and MK-2206 compared to those
treated with mFOLFOX.
SECONDARY OBJECTIVES:
I. To assess the frequency and severity of toxicity associated with the combination of
AZD6244 hydrogen sulfate and MK-2206 compared to those with mFOLFOX in this patient
population.
II. To assess objective tumor response in the subset of patients with measurable disease
(confirmed and unconfirmed complete and partial response) in patients with metastatic
pancreatic cancer treated with the combination of AZD6244 hydrogen sulfate and MK-2206
compared to those treated with mFOLFOX.
III. To bank tissue and blood for future translational medicine studies.
OUTLINE: This is a multicenter study. Patients are stratified according to duration of prior
systemic therapy line (=< 4 months vs > 4 months) and presence of liver metastasis (yes vs
no). Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive oxaliplatin intravenously (IV) over 2 hours on days 1 and 15 and
fluorouracil IV over 46-48 hours on days 1-2 and 15-16 (mFOLFOX).
ARM II: Patients receive Akt inhibitor MK2206 orally (PO) on days 1, 8, 15, and 22, and
selumetinib PO daily on days 1-28.
In all arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.
Blood and paraffin-embedded tumor tissue samples are collected for banking and future
correlative studies.
After completion of study treatment, patients are followed up periodically for 3 years.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Overall survival
From date of registration to death due to any cause using the long-rank test, assessed up to 3 years
No
Vincent Chung
Principal Investigator
Southwest Oncology Group
United States: Food and Drug Administration
NCI-2012-01993
NCT01658943
August 2012
Name | Location |
---|---|
Louisiana State University | New Orleans, Louisiana 70112-2282 |
University of Mississippi Medical Center | Jackson, Mississippi 39216-4505 |
Abington Memorial Hospital | Abington, Pennsylvania 19001 |
University of Washington Medical Center | Seattle, Washington 98195-6043 |
Hurley Medical Center | Flint, Michigan 48503 |
Bronson Methodist Hospital | Kalamazoo, Michigan 49007 |
West Michigan Cancer Center | Kalamazoo, Michigan 49007-3731 |
Borgess Medical Center | Kalamazooaa, Michigan 49001 |
Fairview Ridges Hospital | Burnsville, Minnesota 55337 |
Hutchinson Area Health Care | Hutchinson, Minnesota 55350 |
United Hospital | St. Paul, Minnesota 55102 |
Ridgeview Medical Center | Waconia, Minnesota 55387 |
Avera Cancer Institute | Sioux Falls, South Dakota 57105 |
CentraCare Clinic | Saint Cloud, Minnesota 56303 |
Marshfield Clinic | Marshfield, Wisconsin 54449 |
Sutter Health Western Division Cancer Research Group | Greenbrae, California 94904 |
South Georgia Medical Center | Valdosta, Georgia 31603 |
Ingalls Memorial Hospital | Harvey, Illinois 60426 |
Memorial Hospital of South Bend | South Bend, Indiana 46601 |
Akron General Medical Center | Akron, Ohio 44302 |
Lehigh Valley Hospital | Allentown, Pennsylvania 18103 |
Reading Hospital and Medical Center | Reading, Pennsylvania 19612-6052 |
Martha Jefferson Hospital | Charlottesville, Virginia 22901 |
Waukesha Memorial Hospital | Waukesha, Wisconsin 53188 |
Eastern Maine Medical Center | Bangor, Maine 04401 |
Kaiser Permanente Medical Center - Santa Clara | Santa Clara, California 95051-5386 |
Via Christi Regional Medical Center | Wichita, Kansas 67214 |
Ochsner Clinic Foundation | New Orleans, Louisiana 70121 |
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma 73104 |
Legacy Emanuel Hospital and Health Center | Portland, Oregon 97227 |
Medical Center of Central Georgia | Macon, Georgia 31201 |
Group Health Cooperative | Seattle, Washington 98112 |
Winthrop University Hospital | Mineola, New York 11501 |
MetroHealth Medical Center | Cleveland, Ohio 44109 |
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | Seattle, Washington 98109 |
Cancer Center of Kansas - Chanute | Chanute, Kansas 66720 |
Cancer Center of Kansas - Dodge City | Dodge City, Kansas 67801 |
Cancer Center of Kansas - Newton | Newton, Kansas 67114 |
Cancer Center of Kansas - Salina | Salina, Kansas 67042 |
Cancer Center of Kansas - Wellington | Wellington, Kansas 67152 |
Associates in Womens Health | Wichita, Kansas 67203 |
Cancer Center of Kansas - Winfield | Winfield, Kansas 67156 |
Bozeman Deaconess Hospital | Bozeman, Montana 59715 |
Big Sky Oncology | Great Falls, Montana 59405 |
Kalispell Medical Oncology | Kalispell, Montana 59901 |
Kalispell Regional Medical Center | Kalispell, Montana 59901 |
Adena Regional Medical Center | Chillicothe, Ohio 54601 |
Grady Memorial Hospital | Delaware, Ohio 43015 |
Fairfield Medical Center | Lancaster, Ohio 43130 |
Harborview Medical Center | Seattle, Washington 98104 |
Cancer Care Northwest - Spokane South | Spokane, Washington 99202 |
Welch Cancer Center | Sheridan, Wyoming 82801 |
Elkhart General Hospital | Elkhart, Indiana 46515 |
Front Range Cancer Specialists | Fort Collins, Colorado 80528 |
University Medical Center of Southern Nevada | Las Vegas, Nevada 89102 |
Alta Bates Summit Medical Center - Summit Campus | Oakland, California 94609 |
Sutter Solano Medical Center | Vallejo, California 94589 |
Poudre Valley Hospital | Fort Collins, Colorado 80524 |
Beebe Medical Center | Lewes, Delaware 19958 |
Community Cancer Center of Monroe | Monroe, Michigan 48162 |
Saint Francis Medical Center | Cape Girardeau, Missouri 63701 |
Iredell Memorial Hospital | Statesville, North Carolina 28677 |
Grandview Hospital | Dayton, Ohio 45405 |
Lima Memorial Hospital | Lima, Ohio 45804 |
Mercy Hospital of Tiffin | Tiffin, Ohio 44883 |
Fulton County Health Center | Wauseon, Ohio 43567 |
Legacy Mount Hood Medical Center | Gresham, Oregon 97030 |
Legacy Meridian Park Hospital | Tualatin, Oregon 97062 |
Danville Regional Medical Center | Danville, Virginia 24541 |
Mercy Hospital | Coon Rapids, Minnesota 55433 |
Bixby Medical Center | Adrian, Michigan 49221 |
Saint Joseph Mercy Hospital | Ann Arbor, Michigan 48106 |
Fairview-Southdale Hospital | Edina, Minnesota 55435 |
Abbott-Northwestern Hospital | Minneapolis, Minnesota 55407 |
Regions Hospital | Saint Paul, Minnesota 55101 |
Saint Francis Regional Medical Center | Shakopee, Minnesota 55379 |
Rice Memorial Hospital | Willmar, Minnesota 56201 |
Fox Valley Hematology and Oncology | Appleton, Wisconsin 54911 |
Highland General Hospital | Oakland, California 94602 |
Northeast Georgia Medical Center | Gainesville, Georgia 30501 |
Miami Valley Hospital | Dayton, Ohio 45409 |
Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas 66701 |
Cancer Center of Kansas-Independence | Independence, Kansas 67301 |
Lawrence Memorial Hospital | Lawrence, Kansas 66044 |
Bozeman Deaconess Cancer Center | Bozeman, Montana 59715 |
Wayne Hospital | Greenville, Ohio 45331 |
Knox Community Hospital | Mount Vernon, Ohio 43050 |
Wenatchee Valley Medical Center | Wenatchee, Washington 98801-2028 |
Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire, Wisconsin 54701 |
Saint Joseph's Hospital | Marshfield, Wisconsin 54449 |
Marshfield Clinic - Weston Center | Weston, Wisconsin 54476 |
Diagnostic and Treatment Center | Weston, Wisconsin 54476 |
Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids, Wisconsin 54494 |
Rocky Mountain Oncology | Casper, Wyoming 82609 |
Genesys Regional Medical Center | Grand Blanc, Michigan 48439-8066 |
Greene Memorial Hospital | Xenia, Ohio 45385 |
Harold Alfond Center for Cancer Care | Augusta, Maine 04330 |
Union Hospital of Cecil County | Elkton MD, Maryland 21921 |
Sherman Hospital | Elgin, Illinois 60120-2198 |
Memorial Medical Center | Springfield, Illinois 62781 |
Phelps County Regional Medical Center | Rolla, Missouri 65401 |
Englewood Hospital and Medical Center | Englewood, New Jersey 07631 |
City of Hope | Duarte, California 91010 |
Queen's Medical Center | Honolulu, Hawaii 96813 |
Vanderbilt University | Nashville, Tennessee 37232-6305 |
East Bay Radiation Oncology Center | Castro Valley, California 94546 |
Contra Costa Regional Medical Center | Martinez, California 94553-3156 |
Larry G Strieff MD Medical Corporation | Oakland, California 94609 |
Tahoe Forest Cancer Center | Truckee, California 96161 |
Hennepin County Medical Center | Minneapolis, Minnesota |
University of Rochester | Rochester, New York 14642 |
Glens Falls Hospital | Glens Falls, New York 12801 |
Saint Alphonsus Regional Medical Center | Boise, Idaho 83706 |
El Camino Hospital | Mountain View, California 94040 |
Wayne State University | Detroit, Michigan 48202 |
Riverside Methodist Hospital | Columbus, Ohio 43214 |
Licking Memorial Hospital | Newark, Ohio 43055-2899 |
Cancer Center of Kansas - McPherson | McPherson, Kansas 67460 |
California Pacific Medical Center | San Francisco, California 94115 |
Mid Dakota Clinic | Bismarck, North Dakota 58501 |
Columbus CCOP | Columbus, Ohio 43206 |
Indiana University Medical Center | Indianapolis, Indiana 46202 |
Weiss Memorial Hospital | Chicago,, Illinois 60640 |
Kaiser Permanente | Sacramento, California |
Wichita CCOP | Wichita, Kansas 67214-3882 |
Montana Cancer Consortium CCOP | Billings, Montana 59101 |
Flower Hospital | Sylvania, Ohio 43560-2197 |
Huntsman Cancer Institute/University of Utah | Salt Lake City, Utah 84112 |
Metro-Minnesota CCOP | St. Louis Park, Minnesota |
UC Davis Comprehensive Cancer Center | Sacramento, California 95817 |
Providence Hospital | Southfield, Michigan 48075 |
Lakeview Hospital | Stillwater, Minnesota 55082 |
Decatur Memorial Hospital | Decatur, Illinois 62526 |
Montana Cancer Specialists | Missoula, Montana 59807-7877 |
Florida Hospital | Orlando, Florida 32803 |
University of Chicago Comprehensive Cancer Center | Chicago, Illinois 60637-1470 |
DeKalb Medical Center | Decatur, Georgia 30033 |
Northern Indiana Cancer Research Consortium | South Bend, Indiana |
Castle Medical Center | Kailua, Hawaii 96734 |
Southeast Cancer Center | Cape Girardeau, Missouri 63703 |
New Ulm Medical Center | New Ulm, Minnesota 56073 |
Mills - Peninsula Hospitals | Burlingame, California 94010 |
Valley Medical Oncology Consultants-Castro Valley | Castro Valley, California 94546 |
Valley Medical Oncology Consultants-Fremont | Fremont, California 94538 |
Kaiser Permanente, Fremont | Fremont, California 94538 |
Kaiser Permanente, Hayward | Hayward, California 94545 |
Fremont - Rideout Cancer Center | Marysville, California 95901 |
Bay Area Breast Surgeons Inc | Oakland, California 94609 |
Bay Area Tumor Institution CCOP | Oakland, California 94609 |
Tom K Lee Inc | Oakland, California 94609 |
Kaiser Permanente-Oakland | Oakland, California 94611 |
Kaiser Permanente-Redwood City | Redwood City, California 94063 |
Kaiser Permanente-Richmond | Richmond, California 94801 |
Kaiser Permanente-Roseville | Roseville, California 95661 |
Kaiser Permanente-South Sacramento | Sacramento, California 95823 |
Kaiser Permanente - Sacramento | Sacramento, California 95825 |
Kaiser Permanente-San Francisco | San Francisco, California 94115 |
Kaiser Permanente-Santa Teresa-San Jose | San Jose, California 95119 |
Doctors Medical Center- JC Robinson Regional Cancer Center | San Pablo, California 94806 |
Kaiser Permanente-San Rafael | San Rafael, California 94903 |
Kaiser Permanente-Santa Rosa | Santa Rosa, California 95403 |
Kaiser Permanente-South San Francisco | South San Francisco, California 94080 |
Kaiser Permanente-Stockton | Stockton, California 95210 |
Kaiser Permanente-Vallejo | Vallejo, California 94589 |
Kaiser Permanente-Walnut Creek | Walnut Creek, California 94596 |
Saint Francis Hospital and Medical Center | Hartford, Connecticut 06105 |
Middlesex Hospital | Middletown, Connecticut 06457 |
Edna Williams Cancer Center at the Baptist Cancer Institute | Jacksonville, Florida 32207 |
Saint Joseph's-Candler Health System | Savannah, Georgia 31405 |
Oncare Hawaii Inc-POB II | Honolulu, Hawaii 96813 |
Oncare Hawaii Inc-Kuakini | Honolulu, Hawaii 96817 |
University of Hawaii | Honolulu, Hawaii 96813 |
Joliet Oncology-Hematology Associates Limited | Joliet, Illinois 60435 |
Good Samaritan Regional Medical Center | Mt. Vernon, Illinois 62864 |
Saint Francis Hospital and Health Centers | Beech Grove, Indiana 46107 |
Fort Wayne Medical Oncology and Hematology Inc - State Boulevard | Fort Wayne, Indiana 46845 |
Reid Hospital and Health Care Services | Richmond, Indiana 47374 |
Hematology Oncology Associates-Quad Cities | Bettendorf, Iowa 52722 |
Genesis Medical Center - East Campus | Davenport, Iowa 52803 |
Mercy Medical Center-Sioux City | Sioux City, Iowa 51104 |
Saint Luke's Regional Medical Center | Sioux City, Iowa 51104 |
Cancer Center of Kansas - El Dorado | El Dorado, Kansas 67042 |
Cancer Center of Kansas-Kingman | Kingman, Kansas 67068 |
Cancer Center of Kansas - Parsons | Parsons, Kansas 67357 |
Cancer Center of Kansas - Pratt | Pratt, Kansas 67124 |
Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita, Kansas 67208 |
Cancer Center of Kansas - Main Office | Wichita, Kansas 67214 |
Ochsner Clinic Foundation-Baton Rouge | Baton Rouge, Louisiana 70809 |
DeSoto Regional Health System | Mansfield, Louisiana 71052 |
Louisiana State University Sciences Center- Monroe | Monroe, Louisiana 71210 |
Ochsner Clinic CCOP | New Orleans, Louisiana 70121 |
Highland Clinic | Shreveport, Louisiana 71105 |
Hickman Cancer Center | Adrian, Michigan 49221 |
Michigan Cancer Research Consortium Community Clinical Oncology Program | Ann Arbor, Michigan 48106 |
Oakwood Hospital | Dearborn, Michigan 48123 |
Saint John Hospital and Medical Center | Detroit, Michigan 48236 |
Allegiance Health | Jackson, Michigan 49201 |
Sparrow Hospital | Lansing, Michigan 48912 |
Saint Mary Mercy Hospital | Livonia, Michigan 48154 |
Mercy Memorial Hospital | Monroe, Michigan 48162 |
Saint Joseph Mercy Oakland | Pontiac, Michigan 48341-2985 |
Saint Joseph Mercy Port Huron | Port Huron, Michigan 48060 |
Saint Mary's of Michigan | Saginaw, Michigan 48601 |
Lakeland Hospital | St. Joseph, Michigan 49085 |
Saint John Macomb-Oakland Hospital | Warren, Michigan 48093 |
Unity Hospital | Fridley, Minnesota 55432 |
Saint John's Hospital - Healtheast | Maplewood, Minnesota 55109 |
Minnesota Oncology Hematology PA-Maplewood | Maplewood, Minnesota 55109 |
North Memorial Medical Health Center | Robbinsdale, Minnesota 55422 |
Saint Cloud Hospital | Saint Cloud, Minnesota 56303 |
Park Nicollet Clinic - Saint Louis Park | Saint Louis Park, Minnesota 55416 |
Minnesota Oncology and Hematology PA-Woodbury | Woodbury, Minnesota 55125 |
Saint Louis-Cape Girardeau CCOP | Saint Louis, Missouri 63141 |
Missouri Baptist Medical Center | Saint Louis, Missouri 63131 |
Saint John's Mercy Medical Center | Saint Louis, Missouri 63141 |
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield | Springfield, Missouri 65802 |
Saint John's Hospital | Springfield, Missouri 65804 |
Cox Medical Center | Springfield, Missouri 65807 |
Hematology-Oncology Centers of the Northern Rockies PC | Billings, Montana 59101 |
Saint Vincent Healthcare | Billings, Montana 59101 |
Billings Clinic | Billings, Montana 59107-7000 |
Saint James Community Hospital and Cancer Treatment Center | Butte, Montana 59701 |
Benefis Healthcare- Sletten Cancer Institute | Great Falls, Montana 59405 |
Saint Peter's Community Hospital | Helena, Montana 59601 |
Saint Patrick Hospital - Community Hospital | Missoula, Montana 59802 |
Good Samaritan Hospital | Kearney, Nebraska 68847 |
Nevada Cancer Research Foundation CCOP | Las Vegas, Nevada 89106 |
Cooper Hospital University Medical Center | Camden, New Jersey 08103 |
Veterans Adminstration New Jersey Health Care System | East Orange, New Jersey 07018-1095 |
Orange Regional Medical Center | Middletown, New York 10940 |
Wayne Memorial Hospital | Goldsboro, North Carolina 27534 |
Kinston Medical Specialists PA | Kinston, North Carolina 28501 |
Saint Alexius Medical Center | Bismarck, North Dakota 58501 |
Summa Barberton Hospital | Barberton, Ohio 44203 |
Doctors Hospital | Columbus, Ohio 43228 |
Grant Medical Center | Columbus, Ohio 43215 |
Mount Carmel Health Center West | Columbus, Ohio 43222 |
Good Samaritan Hospital - Dayton | Dayton, Ohio 45406 |
Dayton CCOP | Dayton, Ohio 45429 |
Samaritan North Health Center | Dayton, Ohio 45415 |
Hematology Oncology Center Incorporated | Elyria, Ohio 44035 |
Blanchard Valley Hospital | Findlay, Ohio 45840 |
Atrium Medical Center-Middletown Regional Hospital | Franklin, Ohio 45005-1066 |
Kettering Medical Center | Kettering, Ohio 45429 |
Saint Rita's Medical Center | Lima, Ohio 45801 |
Marietta Memorial Hospital | Marietta, Ohio 45750 |
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee, Ohio 43537 |
Saint Charles Hospital | Oregon, Ohio 43616 |
Toledo Community Hospital Oncology Program CCOP | Toledo, Ohio 43617 |
Mercy Cancer Center at Saint Anne Mercy Hospital | Toledo, Ohio 43623 |
University of Toledo | Toledo, Ohio 43614 |
Saint Vincent Mercy Medical Center | Toledo, Ohio 43608 |
Upper Valley Medical Center | Troy, Ohio 45373 |
Saint Ann's Hospital | Westerville, Ohio 43081 |
Genesis HealthCare System | Zanesville, Ohio 43701 |
Natalie W Bryant Cancer Center | Tulsa, Oklahoma 74136 |
Legacy Good Samaritan Hospital and Medical Center | Portland, Oregon 97210 |
Sanford Cancer Center-Oncology Clinic | Sioux Falls, South Dakota 57104 |
The Don and Sybil Harrington Cancer Center | Amarillo, Texas 79106 |
Fredericksburg Oncology Inc | Fredericksburg, Virginia 22401 |
Harrison Bremerton Hematology and Oncology | Bremerton, Washington 98310 |
Columbia Basin Hematology and Oncology PLLC | Kennewick, Washington 99336 |
Minor and James Medical PLLC | Seattle, Washington 98104 |
Swedish Medical Center-First Hill | Seattle, Washington 98122-4307 |
Sacred Heart Hospital | Eau Claire, Wisconsin 54701 |
Saint Mary's Hospital | Green Bay, Wisconsin 54303 |
Dean Hematology and Oncology Clinic | Madison, Wisconsin 53717 |
Marshfield Clinic-Minocqua Center | Minocqua, Wisconsin 54548 |
Oconomowoc Memorial Hospital-ProHealth Care Inc | Oconomowoc, Wisconsin 53066-3896 |
Marshfield Clinic at James Beck Cancer Center | Rhinelander, Wisconsin 54501 |
Marshfield Clinic-Rice Lake Center | Rice Lake, Wisconsin 54868 |
Saint Michael's Hospital | Stevens Point, Wisconsin 54481 |
Marshfield Clinic-Wausau Center | Wausau, Wisconsin 54401 |
University of California Medical Center At Irvine-Orange Campus | Orange, California 92868 |
Roger Maris Cancer Center | Fargo, North Dakota 58122 |
Elkhart Clinic | Elkhart, Indiana 46515 |
Michiana Hematology Oncology PC-Elkhart | Elkhart, Indiana 46514 |
Michiana Hematology Oncology PC-Plymouth | Plymouth, Indiana 46563 |
Michiana Hematology Oncology PC-South Bend | South Bend, Indiana 46601 |
Michiana Hematology Oncology-PC Westville | Westville, Indiana 46391 |
Cancer Center of Kansas-Liberal | Liberal, Kansas 67901 |
University of Michigan University Hospital | Ann Arbor, Michigan 48109 |
UMDNJ - New Jersey Medical School | Newark, New Jersey 07103 |
Community Health Partners Regional Medical Center | Elyria, Ohio 44035 |
Erlanger Medical Center | Chattanooga, Tennessee 37403 |
Skagit Valley Hospital | Mt. Vernon, Washington 98273 |
Evergreen Hematology and Oncology PS | Spokane, Washington 99218 |
West Virginia University Charleston | Charleston, West Virginia 25304 |
Marshfield Clinic-Chippewa Center | Chippewa Falls, Wisconsin 54729 |
Marshfield Clinic Cancer Care at Saint Michael's Hospital | Stevens Point, Wisconsin 54481 |
State University of New York Downstate Medical Center | Brooklyn, New York 11203 |
Texas Tech University Health Sciences Center | Lubbock, Texas 79430 |
Kaiser Permanente Los Angeles Medical Center | Los Angeles, California 90027 |
FirstHealth of the Carolinas-Moore Regional Hosiptal | Pinehurst, North Carolina 28374 |
Kaiser Anaheim Medical Center | Anaheim, California 92807 |
Kaiser Permanente-Deer Valley Medical Center | Antioch, California 94531 |
Kaiser Foundation Hospital | Bellflower, California 90706 |
Epic Care-Oakland | Oakland, California 94612 |
Kaiser Permanente - Panorama City | Panorama City, California 91402 |
Kaiser Permanente Health Care | San Marcos, California 92069 |
Kaiser Permanente Medical Center-Vacaville | Vacaville, California 95688 |
Kaiser Permanente-Rock Creek | Lafayette, Colorado 80026 |
Kaiser Permanente Moanalua Medical Center | Honolulu, Hawaii 96819 |
Capital Region Medical Center-Goldschmidt Cancer Center | Jefferson City, Missouri 65109 |
Saint John's Clinic-Rolla-Cancer and Hematology | Rolla, Missouri 65401 |
Kings County Hospital | Brooklyn, New York 11203 |
The Mark H Zangmeister Center | Columbus, Ohio 43219 |
Southern Ohio Medical Center | Portsmouth, Ohio 45662 |
Cancer Care Center at Island Hospital | Anacortes, Washington 98221 |
Highline Medical Center-Main Campus | Burien, Washington 98166 |
United General Hospital | Sedro-Woolley, Washington 98284 |
Legacy Salmon Creek Hospital | Vancouver, Washington 98686 |
Gundersen Lutheran | La Crosse, Wisconsin 54601 |
Central Indiana Cancer Centers - Indianapolis | Indianapolis, Indiana 46227 |
Kaiser Permanente-Franklin | Denver, Colorado 80205 |
Siouxland Hematology Oncology Associates | Sioux City, Iowa 51101 |
Swedish Cancer Institute-Issaquah | Issaquah, Washington 98029 |
Marshfield Clinic - Ladysmith Center | Ladysmith, Wisconsin 54848 |
Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California 94704 |
Michiana Hematology Oncology PC-Mishawaka | Mishawaka, Indiana 46545-1470 |
Marie Yeager Cancer Center | Saint Joseph, Michigan 49085 |
Sanford Clinic North-Fargo | Fargo, North Dakota 58102 |
Sanford Medical Center-Fargo | Fargo, North Dakota 58122 |
Summa Akron City Hospital | Akron, Ohio 44304 |
Franciscan St. Francis Health | Indianapolis, Indiana 46237 |
The Toledo Hospital/Toledo Children's Hospital | Toledo, Ohio 43606 |
Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota 57117-5134 |
Sanford Clinic North-Bemidgi | Bemidji, Minnesota 56601 |
Sanford Bismarck Medical Center | Bismarck, North Dakota 58501 |
Toledo Clinic Cancer Centers-Oregon | Oregon, Ohio 43616 |
Community Howard Regional Health | Kokomo, Indiana 46904 |
Indiana University Health La Porte Hospital | La Porte, Indiana 46350 |
Saint Joseph Regional Medical Center-Mishawaka | Mishawaka, Indiana 46545-1470 |
PeaceHealth Saint Joseph Medical Center | Bellingham, Washington 98225 |
Christiana Care Health System-Christiana Hospital | Newark, Delaware 19718 |
Springfield Regional Medical Center | Springfield, Ohio 45505 |
Saint Louis Cancer and Breast Institute-South City | Saint Louis, Missouri 63109 |
Toledo Clinic Cancer Centers-Bowling Green | Bowling Green, Ohio 43402 |
Toledo Clinic Cancer Centers-Maumee | Maumee, Ohio 43537-1839 |
Toledo Clinic Cancer Centers-Toledo | Toledo, Ohio 43623 |
Guthrie Clinic-Robert Packer Hospital | Sayre, Pennsylvania 18840 |
Harrison Poulsbo Hematology and Oncology | Poulsbo, Washington 98370 |
Sutter Pacific Medical Foundation | Santa Rosa, California 95403 |
OnCare Hawaii-Liliha | Honolulu, Hawaii 96817-3169 |
Ochsner Baptist Medical Center | New Orleans, Louisiana 70115 |
Cancer Center of Western Wisconsin | New Richmond, Wisconsin 54017 |
Saint Clare's Hospital | Weston, Wisconsin 54476 |
Oncare Hawaii Inc - Kapiolani Medical Center at Pali Momi | Aiea, Hawaii 96701 |
D N Greenwald Center | Mukwonago, Wisconsin 53149 |
Swedish Medical Center-Edmonds | Edmonds, Washington 98026 |
Idaho Urologic Institute PA | Meridian, Idaho 83642 |
Kaiser Permanente-Modesto | Modesto, California 95356 |