Inclusion Criteria:

Subjects must meet all of the following major inclusion criteria to be eligible for the
study:

1. 18 years of age or older

2. Histologically or cytologically documented stage IV ductal adenocarcinoma of the
pancreas.

3. Performance Status (ECOG) 0 or 1

4. FFPE tumor tissue from metastatic site(s

5. Adequate organ function

6. Written consent on an IRB/IEC-approved Informed Consent Form prior to any
study-specific evaluation.

7. For women of child-bearing potential, negative serum pregnancy test at screening and
use of physician-approved method of birth control from 30 days prior to the first
study drug administration to 30 days following the last study drug administration.

8. Male subjects must be surgically sterile or must agree to use physician-approved
contraception from 30 days prior to the first study drug administration to 30 days
following the last study drug administration.

Exclusion Criteria:

Subjects who meet any of the following major exclusion criteria will not be eligible for
participation in the study:

1. Neuroendocrine tumors (i.e., carcinoid, islet cell cancer) of the pancreas.

2. Known brain metastases.

3. Prior therapy, including systemic therapy, surgical resection or radiation for newly
diagnosed stage IV pancreatic cancer.

4. Presence of any serious or unstable concomitant systemic disorder incompatible with
the clinical study (e.g., substance abuse, uncontrolled intercurrent illness
including active infection, arterial thrombosis, symptomatic pulmonary embolism).

5. Any disorder that would significantly compromise protocol compliance.

6. Prior non-pancreatic malignancy treated with chemotherapy. Prior malignancies
treated with surgery and/or radiotherapy alone must be in remission ≥3 years. The
following prior malignancies are allowable irrespective of when they occurred: in
situ carcinoma of the cervix, in situ ductal breast cancer, low-grade local bladder
cancer, and nonmelanotic skin cancer.

7. Known human immunodeficiency virus (HIV) infection.

8. Females who are pregnant or breastfeeding.