Inclusion Criteria:

- This trial treats subjects with relapsing variants of MS, including
relapsing-remitting, progressive-relapsing, transitional, or secondary progressive
MS, not amenable to other aggressive therapy, prior relapses, EDSS 2.5-7.0 inclusive.
Most will have generally moderate to severe disability at EDSS >3 (EDSS 2.5-3 if
significant cognitive complaints or MRI activity). Alemtuzumab experienced subjects
at any EDSS level previously treated with alemtuzumab outside of a clinical trial are
also eligible.

Inclusion Criteria for Alemtuzumab Experienced Subjects:

- All clinic patients who have been treated with alemtuzumab with our clinic method
will be offered participation in the study, and may leave the study if desired after
collection of data. Subjects wishing to sign informed consent but who have moved out
of the region and are unable to be seen personally may be interviewed by telephone
and included in the database after signing informed consent.

Exclusion Criteria:

- Subjects are excluded if they have purely slowly progressive or definite primary
progressive MS (e.g. slowly progressive corticosteroid unresponsive myelopathy) with
no documented recent relapses, advanced age (over 75 years), legal minor status, or a
recognized contraindication to alemtuzumab (active infection, malignancy (other than
considered surgical cures by oncologist or basal cell carcinoma), uncontrolled
bleeding disorder, planned pregnancy in immediate future or unwillingness to use
contraception, or if they are in another alemtuzumab clinical trial.

- Prior autoimmunity which is in remission or controlled will be considered at the
investigator's discretion.

- Our clinic experience is that prior Grave's disease is not a contraindication to
alemtuzumab therapy.

- We have not previously excluded patients from alemtuzumab on the basis of any humoral
immune marker (e.g. anti-thyroid), and therefore do not plan to perform such testing
in screening.