Cognitive Changes After Surgery in the Elderly: Does Minimally Invasive Surgery Influence the Incidence of Postoperative Cognitive Changes Compared to Open Colon Surgery?
65 Years
N/A
Both
Confusion, Inflammation, Acute Phase Reaction, Surgery, Delirium
Trial Information
Cognitive Changes After Surgery in the Elderly: Does Minimally Invasive Surgery Influence the Incidence of Postoperative Cognitive Changes Compared to Open Colon Surgery?
Cognitive changes in the elderly are common after surgery. It is not known if minimally
invasive or laparoscopic surgery can prevent these changes. A study will be conducted on
patients scheduled to have abdominal surgery. The patients will have cognitive evaluations
before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no
more than 5 times in 6 months. The results will be analyzed to determine if there are
changes between those having open surgery versus patients having laparoscopic or minimally
invasive surgery, and if these changes coincide with cognitive changes.
Inclusion Criteria:
- Patients over age 65.0 years and in need of elective colon resection for
adenocarcinoma
Exclusion Criteria:
- Inability to complete preoperative cognitive screening
- Inability to complete study in English since CANTAB is timed and not validated with
interpreters
- Emergency surgery
- Depression or psychiatric comorbidity
- Pre-existing dementia
- Previous cerebrovascular accident or "stroke"
- Previous myocardial infarction
- Cardiac ejection fraction below 55%
- Propranolol, metoprolol or other betablocker use
- Digoxin, procainamide, or amiodarone use
- Calcium channel blocker use
- History of vascular surgery or arterial vascular disease
- History of alcohol dependence
- Lovastatin or other HMG-CoA reductase inhibitor use
- Ace inhibitor use
- Neuroendocrine or catecholamine associated tumors
- Hypertension
- Diabetes
- Benzodiazepine use
- Dimenhydrinate or other medications to treat motion sickness
- Metaclopramide use
Type of Study:
Observational
Study Design:
Observational Model: Case Control, Time Perspective: Prospective
Outcome Measure:
Confusion
Outcome Description:
Confusion assessed by questionaires and cognitive testing
Outcome Time Frame:
6 Months
Safety Issue:
No
Principal Investigator
Mitchell I Chorost, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
New York Hospital Queens
Authority:
United States: Institutional Review Board
Study ID:
ECRIP
NCT ID:
NCT01623297
Start Date:
January 2012
Completion Date:
January 2015
Related Keywords:
- Confusion
- Inflammation
- Acute Phase Reaction
- Surgery
- Delirium
- Laparoscopy
- Surgery
- Acute Phase Reaction
- Aged
- Aged 80 and over
- Confusion
- Inflammation
- Delirium
- Acute-Phase Reaction
- Confusion
- Delirium
- Inflammation
Name | Location |
|---|---|
| New York Hospital Queens | Flushing, New York 11355 |
