Phase II Trial of Reduced Intensity Conditioning (RIC) and Allogeneic Transplantation of Umbilical Cord Blood (UCB) From Unrelated Donors in Patients With Hematologic Malignancies

Inclusion Criteria:

Subjects 18-70 years old. ECOG 0-2

Patients must have a diagnosis of one of the following:

- Chronic Myeloid Leukemia

- Acute Myeloid Leukemia

- Acute Lymphoblastic Leukemia

- Hodgkin's Disease

- Non-Hodgkins Lymphoma

- Myelodysplastic Syndromes

- Myeloproliferative Disorder

Patients must have adequate visceral organ function

- Patients must furnish written informed consent and HIPAA authorization for release of
personal health information.

- Patients must be able to understand the requirements of the study, abide by the study
restrictions, and agree to return for the required assessments.

Exclusion Criteria:

- Patients who have a histocompatible sibling-matched donor age 18 to 65 years in good
health who is willing to donate stem cells are ineligible.

- Patients who are pregnant are ineligible.

- Patients are ineligible if they have received cumulative chemotherapy doses in excess
of: carmustine (BCNU) 400 mg/m2, and/or a cumulative anthracycline exposure in excess
of 550 mg/m2 doxorubicin (Adriamycin®) unless gated-pool radionuclide cardiac scan
shows greater than/equal to 45% ejection fraction.

Patients who are HIV or HTLV-I, -II antibody sero-positive are ineligible.