A Proof of Principle Study of Aminolevulinic Acid (ALA) - Induced Fluorescence Detection in Resectable Non-Small Cell Lung Cancer

Inclusion Criteria:

- Inclusion Criteria Patients (12 total patients with lung cancer) meeting eligibility
criteria will be enrolled.

- Preoperative diagnosis of either presumed or documented non-small cell lung cancer.

- Tumor judged to be suitable for surgical resection based on preoperative evaluation
of radiographic studies, pulmonary function tests, performance status and clinical
judgment of surgeons at DHMC (Erkmen, Nugent)

- Age ≥ 18 years old.

- Population representative of our usual referral pattern including minority
populations, women and those who are financially disadvantaged.

- Subjects capable of giving informed consent

Exclusion Criteria:

- Pregnant Women

- Women who are breast feeding

- History of cutaneous photosensitivity

- Porphyria, hypersensitivity to porphyrins, photodermatosis

- Exfoliative dermatitis

- History of liver disease within the last 12 months

- Inability to comply with photosensitivity precautions associated with the study

- Inability to give informed consent

- AST, ALT, ALP or bilirubin levels greater than 2.5 times the normal limit at any time
during the past 2 months

- Plasma creatinine in excess of 180 umol/L

- Women who are breast feeding

- History of cutaneous photosensitivity

- Porphyria, hypersensitivity to porphyrins, photodermatosis

- Exfoliative dermatitis

- History of liver disease within the last 12 months

- Inability to comply with photosensitivity precautions associated with the study