Inclusion Criteria

Criteria that need to be met to participate in this study:

- Patients must be > 12 months and < 30 years of age when registered on study.

- Patients must have relapsed neuroblastoma, refractory neuroblastoma that had less
than a partial response to standard treatment or persistent neuroblastoma that had at
least a partial response to standard treatment. All patients must have at least ONE
site of evaluable disease.

o Patients who have at least a partial response to standard treatment who still have
neuroblastoma that can be seen on CT/MRI or MIBG scans must have a surgical biopsy
done of the tumor to confirm that it is neuroblastoma. Patients with relapsed or
refractory neuroblastoma do not need to have a biopsy done to enter on study.

- Patients must have adequate heart, kidney, liver and bone marrow function. Patients
who have bone marrow disease must still have adequate bone marrow function to enter
the study.

- MLN8237 must be swallowed as whole tablets. Therefore, patients must be able to
swallow pills to be eligible for study. One tablet is the size of small breath mint,
or baby aspirin. Due to the size of MLN8237 tablets, patients must have a body
surface area of at least 0.38 m2 to be eligible for study. A body surface area is a
combination of a patient's height and weight. An example of a child with a BSA of
0.45 is a child that is 25 inches tall and weighs 25 pounds.You can use the link
below to calculate your child's body surface area and determine if they are too small
for this trial.

Patients cannot participate in the study if:

- Patients who have received prior MLN8237 are excluded from all phases of the study.
Patients previously treated with irinotecan and/or temozolomide will be eligible if
they have not had documented progressive disease during treatment with a regimen
containing these agents.

- They have other medical problems that could get much worse if they had this
treatment.

- They are on dialysis for bad kidney function.

- They are pregnant or breast feeding.

- They have active infections such as hepatitis or fungal infections.

- They have an allergy to treatment with cefixime and cefpodixime.

- They have brain metastasis at study entry, or have received cranial spinal radiation.

- They have had an allogeneic stem cell transplant (received stem cell from someone
else).

- They can't cooperate with the special precautions that are needed for this trial.