Trial Information

N2004-05: Neuroblastoma Biology Study

The purposes of this study are:

To establish a storage place or bank of samples of blood, bone marrow, and/or tumor, and
molecular components isolated from these samples from children with neuroblastoma. The
stored specimens will be shared with laboratory researchers studying high risk
neuroblastoma.

To evaluate a new test of blood and bone marrow specimens to find tumor cells. The results
of this new test, called 5-gene TaqMan® Low Density Array or TLDA, will be compared between
blood and bone marrow and imaging (radiology) studies. Radiology studies (CT scans, MRI
scans, and MIBG scans) and the TLDA test will be compared for their ability to measure the
amount of tumor present and how this changes with therapy.

To collect clinical data (such as treatments received, date of diagnosis, tumor stage, etc)
and radiology scans to provide this information as needed for the laboratory studies to be
done on the specimens.

To obtain neuroblastoma tumor cells from tumor tissue, bone marrow, and/or blood to use to
start cell lines, or tumor cells that will keep growing in the laboratory. These cell lines
will be shared with laboratory researchers studying high risk neuroblastoma.