Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) Performance Status 0 2

- Histologically-confirmed metastatic melanoma (unresectable Stage IIIc or IV) with an
activating BRAF mutation other than V600E

- Measurable disease (as defined by RECIST, v1.1)

- Adequate recovery from most recent systemic or local treatment for cancer

- Adequate organ function

- Women of childbearing potential and male partners of women of childbearing potential:
agreement to use prescribed contraception.

- Negative serum pregnancy test within 7 days of commencement of treatment in
premenopausal women. Women who are either surgically sterile or have been
post-menopausal for at least 1 year are eligible to participate in this study

- Agreement not to donate blood or blood products during the study and for at least 6
months after discontinuation of vemurafenib; for male patients, agreement not to
donate sperm during the study and for at least 6 months after discontinuation of
vemurafenib

Exclusion Criteria:

- Invasive malignancy other than melanoma at the time of enrollment and within 2 years
prior

- Pregnant or breast-feeding

- Concurrent anti-tumor therapy (e.g., chemotherapy, other targeted therapy, radiation
therapy, including participation in an experimental drug study)

- Either a concurrent condition or history of a prior condition that places the patient
at unacceptable risk if he/she were treated with the study drug or confounds the
ability to interpret data from the study

- Ongoing cardiac dysrhythmia >/= Grade 2