Inclusion Criteria:

- Age ≥ 18 years of age; male or female.

- Histologically or cytologically confirmed, locally advanced, unresectable, and/or
metastatic pancreatic ductal adenocarcinoma.

- Cancer progression after treatment with one gemcitabine and one
fluoropyrimidine-containing chemotherapy regimen.

- Capable of providing informed consent and complying with trial procedures.

- ECOG performance status 0-1.

- Life expectancy ≥ 8 weeks.

- Measurable tumor lesions according to RECIST 1.1 criteria.

- Women must not be able to become pregnant (eg post-menopausal for at least 1 year,
surgically sterile, or practicing adequate birth control methods) for the duration of
the study. (Adequate contraception includes: oral contraception, implanted
contraception, intrauterine device implanted for at least 3 months, or barrier method
in conjunction with spermicide.)

- Women of child bearing potential must have a negative serum or urine pregnancy test
at the Screening Visit and be non-lactating.

- Geographic accessibility to the site.

Exclusion Criteria:

- Prior exposure to > 3 cycles or 225 mg/m2 of doxorubicin or Doxil®.

- Palliative surgery and/or radiation treatment less than 4 weeks prior to
Randomization.

- Exposure to any investigational agent within 30 days of Randomization.

- Evidence of central nervous system (CNS) metastasis (negative imaging study, if
clinically indicated, within 4 weeks of Screening Visit).

- History of other malignancies (except cured basal cell carcinoma, superficial bladder
cancer or carcinoma in situ of the cervix) unless documented free of cancer for ≥ 5
years.

- Laboratory values: Screening serum creatinine > 1.5x upper limit of normal (ULN),
alanine aminotransferase (ALT) > 3×ULN or > 5×ULN if liver metastases are present,
total bilirubin > 3×ULN, absolute neutrophil count < 1,500/mm3, platelet
concentration < 100,000/mm3, absolute lymphocyte count < 1000/mm3, hematocrit level
< 27% for females or < 30% for males, or coagulation tests (prothrombin time [PT],
partial thromboplastin time [PTT], International Normalized Ratio [INR]) > 1.5×ULN,
serum albumin ≤ 2.8 g/dL.

- Clinically evident congestive heart failure > class II of the New York Heart
Association (NYHA) guidelines.

- Current, serious, clinically significant cardiac arrhythmias, defined as the
existence of an absolute arrhythmia or ventricular arrhythmias classified as Lown
III, IV or V.

- History or signs of active coronary artery disease with or without angina pectoris.

- Serious myocardial dysfunction ultrasound-determined, with absolute left ventricular
ejection fraction (LVEF) < 45% of predicted.

- History of HIV infection.

- Active, clinically significant serious infection requiring treatment with
antibiotics, anti-virals or anti-fungals.

- Major surgery within 4 weeks prior to Randomization.

- Substance abuse or any condition that might interfere with the subject's
participation in the study or in the evaluation of the study results.

- Any condition that is unstable and could jeopardize the subject's participation in
the study.