Inclusion Criteria:

Patients eligible for inclusion in this study must meet all of the following criteria:

- SCLC pathologically confirmed at MSKCC.

- Untreated ES- SCLC, defined as those patients with extrathoracic metastatic disease,
malignant pleural effusion, bilateral or contralateral supraclavicular
lymphadenopathy, or contralateral hilar adenopathy.

- Age 18 years or older.

- Karnofsky Performance Status ≥ 70.

- Presence of at least one measurable site of disease as defined by Response Evaluation
Criteria in Solid Tumors 1.1 (RECIST 1.1).

- Adequate bone marrow, liver and renal function, as specified below:

- Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L

- Hemoglobin (Hgb) ≥ 9 g/dL

- Platelets ≥ 100 x 109/L

- Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN )

- AST and ALT ≤ 2.5 x ULN or ≤ 5 x ULN if liver metastases are present

- Plasma creatine phosphokinase (CK) < 1.5 x ULN

- Serum creatinine ≤ 1.5 x ULN OR creatinine clearance ≥ 60ml/min for patients with
creatinine levels above institutional normal.

- Patients with asymptomatic CNS metastases will be eligible. For patients that have
undergone radiation therapy for their CNS metastases, a minimum of 14 days must
elapse prior to study registration, and patients must have recovered from any adverse
events related to radiotherapy with the exception of alopecia and grade 1 neuropathy.

Exclusion Criteria:

Patients eligible for this study must not meet any of the following criteria:

- Patients who have had major surgery within 4 weeks of initiation of study medication.

- Patients who are unable to take oral drugs.

- Patients who have previously been treated with systemic LDE225 or with other Hh
pathway inhibitors.

- Patients who have taken part in an experimental drug study within 4 weeks of
initiating treatment with LDE225.

Patients who are receiving other anti-neoplastic therapy (e.g. chemotherapy, targeted
therapy, or radiotherapy) concurrently or within 2 weeks of starting treatment.

- Patients who have neuromuscular disorders (e.g. inflammatory myopathies, muscular
dystrophy, amyotrophic lateral sclerosis and spinal muscular atrophy).

- Patients who are on concomitant treatment with drugs that are contraindicated in this
study and that cannot be discontinued within the time frames as listed.

- Patients who are planning on embarking on a new strenuous exercise regimen that can
result in significant increases in plasma CK levels.

- Patients who are receiving treatment with medications known to be moderate and strong
inhibitors or inducers of CYP3A4/5 or with drugs metabolized by CYP2B6 or CYP2C9 that
have narrow therapeutic index that cannot be discontinued before starting treatment
with LDE225. Medications that are strong CYP3A4/5 inhibitors should be discontinued
at least 7 days and strong CYP3A/5 inducers should be discontinued for at least 14
days prior to starting treatment with LDE225 Some of these medications are recognized
to cause rhabdomyolysis.)

- Patients who are receiving treatment with statins that are known to cause
rhabdomyolysis and that cannot be discontinued at least 2 days prior to starting
LDE225 treatment.

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, or psychiatric illness/social situations that would limit compliance with
study requirements.

Impaired cardiac function or clinically significant heart disease, including any one of
the following: congestive heart failure, angina pectoris within 3 months, acute myocardial
infarction within 3 months, QTcF > 450 msec for males and > 470 msec for females on the
screening ECG, history of clinically significant ECG abnormalities, family history of
prolonged QT-interval syndrome, or other clinically significant heart disease (e.g.
congestive heart failure, uncontrolled hypertension, history of labile hypertension, or
history of poor compliance with an antihypertensive regimen).

- Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
female after conception and until the termination of gestation, confirmed by a
positive hCG laboratory test (> 5 mIU/mL).

- Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant, unless they are using highly effective methods of contraception
during dosing and 4 months after the last study treatment. Highly effective
contraception methods include the following:

Total abstinence or

- Male or female sterilization or

- Combination of any two of the following (a+b or a+c, or b+c):

- Use of oral, injected, or implanted hormonal methods of contraception

- Placement of an intrauterine device (IUD) or intrauterine system (IUS)

- Barrier methods of contraception: condom or occlusive cap (diaphragm or
cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository

- Women are considered post-menopausal and not of child bearing potential if
they have had 12 months of natural (spontaneous) amenorrhea with an
appropriate clinical profile (e.g. age appropriate, history of vasomotor
symptoms) or have had surgical bilateral oophorectomy (with or without
hysterectomy) or tubal ligation at least six weeks prior to initiation of
the study. In the case of oophorectomy alone, only when the reproductive
status of the woman has been confirmed by follow up hormone level
assessment is she considered not of child bearing potential.

- Sexually active males must use a condom during intercourse while taking the
drug and for 6 months after stopping treatment and should not father a
child in this period. A condom is required to be used also by vasectomized
men in order to prevent delivery of the drug via seminal fluid.