MRI-Guided Laser-Induced Thermal Therapy for Cytoreduction of Inoperable Grade III/IV GLiomas Prior to Chemotherapy and Radiation

Trial Information

MRI-Guided Laser-Induced Thermal Therapy for Cytoreduction of Inoperable Grade III/IV GLiomas Prior to Chemotherapy and Radiation

Laser induced thermal therapy (LITT) is a procedure for destroying tissue through generation
of heat. When used in conjunction with fiberoptic applicators, it offers an excellent means
of minimally invasive surgery. As opposed to other thermal techniques like radio-frequency
(RF) ablation, or cryo-ablation, LITT may be significantly faster and may exhibit sharper
boundary of the thermal ablation zone. More importantly, LITT is highly compatible with MR
imaging and when coupled with MR thermal imaging (MRTI) guidance, precise monitoring of the
thermal ablation zone in order to avoid eloquent or critical structures is possible.

In this study, we propose to evaluate MR-thermal image guided laser interstitial therapy for
the treatment of inoperable brain tumors as upfront therapy prior to initiation of
chemotherapy and radiation. MR-thermal imaging (MRTI) will be used to provide information
on thermal dose delivered to the target and be used to control laser delivery to prevent
damage to critical structures.