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Phosphoproteomic Patterns as a Novel Biomarker for Aurora and Polo-like Kinase Inhibitors in Non-Small Cell Lung Cancer


N/A
18 Years
N/A
Open (Enrolling)
Both
Non-Small Cell Lung Cancer

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Trial Information

Phosphoproteomic Patterns as a Novel Biomarker for Aurora and Polo-like Kinase Inhibitors in Non-Small Cell Lung Cancer


Inclusion Criteria:



- Subjects undergoing or who have undergone thoracic surgery for presumed lung cancer

- Wedge resection, lobectomy, bilobectomy, segmentectomy and pneumonectomy thoracic
surgical operations are permitted.

- Age ≥ 18 years.

- Subject meets criteria for thoracic surgery as determined by the thoracic surgeon.

- Able to provide written informed consent.

Exclusion Criteria:

- Subjects undergoing or who have undergone thoracic surgery for metastatic disease
from other primary sources such as colorectal cancer, sarcoma, melanoma, breast
cancer, bladder cancer, prostate cancer, esophageal cancer, pancreatic cancer, or
gastric cancer will be excluded.

- Subjects who have received prior preoperative lung cancer anticancer therapy will be
excluded.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Correlation between the Phosphoproteomic expression pattern of specific substrates of Aurora Kinase A and/or Polo-like kinase 1 (PLK1)

Outcome Description:

Correlation of phosphoproteomic expression patterns of specific substrates of Aurora kinase A and/or Polo-like kinase 1 and disease-free survival in surgically resected NSCLC. (Disease-free survival is defined as the time from surgical resection until the first documentation of disease recurrence or death.)

Outcome Time Frame:

2 years

Safety Issue:

No

Principal Investigator

James R Rigas, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center

Authority:

United States: Institutional Review Board

Study ID:

D1026

NCT ID:

NCT01510405

Start Date:

July 2010

Completion Date:

December 2013

Related Keywords:

  • Non-Small Cell Lung Cancer
  • Subjects undergoing or who have undergone thoracic surgery for presumed lung cancer.
  • The following procedures are allowed: Wedge resection, lobectomy, bilobectomy, segmentectomy and pneumonectomy thoracic surgical operations are permitted.
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location
Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756