Trial Information

This project will determine the efficacy of vitamin D3 supplements for reducing side effects
of treatment with aromatase inhibitors in women with a history of breast cancer that have no
evidence of current disease. The aromatase inhibitors (AI) have become a critical
component of adjuvant therapy for this population, but they cause bone pain, joint pain,
joint stiffness, and muscle weakness in approximately 40% of patients. These symptoms,
referred to as aromatase inhibitor-associated musculoskeletal symptoms (AIMSS), decrease
quality of life and medication adherence. Identifying effective ways to decrease these
symptoms may allow for longer and more adherent medication use and thus may improve
disease-free survival. We hypothesize that vitamin D3 may decrease symptoms associated with
the use of aromatase inhibitors.