A Phase II Trial to Evaluate the Use of Trental and Vitamin E for Prophalaxis of Radiation Necrosis

Inclusion Criteria:

- Plan to undergo single or five fraction radiosurgery for a metastatic brain tumor

- Diagnosis of a metastatic brain tumor may be accomplished by histologic confirmation
or by clinical confirmation by the treating physician based on MR imaging
characteristics in the setting of a known history of cancer

- Age > 18 years

- Partial or total resection of a metastatic tumor are eligible

Exclusion Criteria:

- Known sensitivity to vitamin E or Trental

- Recent intracranial bleed or retinal hemorrhage

- Treatment with a non-approved or investigational drug within 30 days before day 1 of
study treatment

- History of Avastin treatment

- Anticipated need for treatment with Avastin

- History of bleeding disorder

- History of liver disorder