Trial Information

A Prospective Observational Study of Maintenance Plasma Exchange (PLEX) for Neuromyelitis Optica Spectrum Disorders (MultiPLEX Study)

Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system that is
associated with autoantibodies to aquaporin-4. Treatment options for prevention of clinical
relapses of NMO include immunosuppressive medications. Plasma exchange (PLEX) is commonly
used as a rescue therapy for NMO relapses but ongoing, regular PLEX procedures (maintenance
PLEX) is sometimes used to prevent relapses. This observational registry will record
feasibility, tolerability, safety, and preliminary efficacy data regarding maintenance PLEX
for participants with NMO, NMO spectrum disorders, and recurrent idiopathic longitudinally
extensive transverse myelitis.