A Phase II Trial of Sequential SGN-35 Therapy With Adriamycin, Vinblastine, and Dacarbazine (S-AVD) for Older Patients With Untreated Hodgkin Lymphoma

Inclusion Criteria:

- Voluntary written informed consent before performance of any study-related procedure
not part of normal medical care, with the understanding that consent may be withdrawn
by the subject at any time without prejudice to future medical care

- Previously untreated classical Hodgkin lymphoma (i.e., nodular sclerosis, mixed
cellularity, lymphocyte depleted, lymphocyte-rich, and not otherwise specified
[NOS]); nodular lymphocyte predominant Hodgkin lymphoma is not eligible

- Stage II, III, and IV disease by Ann Arbor classification

- Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2

- Patients must have bi-dimensional measurable disease documented in the lymphoma
baseline tumor assessment form within 30 days prior to registration (at least 1.5
cm); patients with non-measurable disease in addition to measurable disease must have
been assessed within 60 days prior to registration

- Patients must have a bone marrow biopsy (bilateral preferred, unilateral acceptable)
within 60 days prior to registration

- Patients must have a multi gated acquisition scan (MUGA) or echocardiogram within 60
days prior to study registration and the ejection fraction must be >= 45%

- Absolute neutrophil count (ANC) > 1000/mm^3

- Platelet count > 75,000/mm^3

- Creatinine < 2.5 mg/dl

- Bilirubin < 3.0 mg/dl

- Patients with documented marrow involvement by lymphoma at the time of registration
are not required to meet the above hematologic parameters

- Patients must not have received prior chemotherapy or radiation therapy for the
treatment of Hodgkin lymphoma

- Both females and males who have partners of childbearing potential must agree to use
an effective contraceptive method during the study and for 30 days following the last
dose of study drug

- Patients must sign the informed consent form before registration

Exclusion Criteria:

- Previous treatment with brentuximab vedotin or any other prior anti-CD30-based
antibody therapy

- History of another primary malignancy that has not been in remission for at least 3
years; (the following are exempt from the 3-year limit: early stage [stage I or II]
breast cancer treated with surgery and radiation +/- hormones [without adjuvant
chemotherapy], non-melanoma skin cancer, fully excised melanoma in situ [stage 0],
curatively treated localized prostate cancer, and cervical carcinoma in situ on
biopsy or a squamous intraepithelial lesion on Papanicolaou test [PAP smear])

- Known cerebral/meningeal disease

- Any active systemic viral, bacterial, or fungal infection requiring treatment with
antimicrobial therapy within 1 week prior to first dose

- Patients with hepatitis B surface antigen (HBsAg) positive hepatitis B virus (HBV)
infection; patients with prior history of hepatitis B infection, but immune, with
only Immunoglobulin G (IgG) hepatitis core antibody + (HBcAb +) must receive
anti-viral prophylaxis (e.g., lamivudine 100mg orally [po] daily) for at least 1 week
prior to cycle 1 and throughout induction and continuation therapy and for at least 6
months after the last brentuximab vedotin dose; in addition, consultation with a
hepatologist is recommended

- Patients with a known hypersensitivity to any excipient contained in the drug
formulation

- Patients with dementia or an altered mental state that would preclude the
understanding and rendering of informed consent