Pilot Study of Neuropsychologic and Electrophysiological Features of Cancer-Related Cognitive Side Effects in Racial and Ethnic Minority Breast Cancer Patients

Inclusion Criteria:

- Is at least 18 years old, but not older than 61 years old;

- Is female;

- Is Hispanic of any race or Black/African American

- Is fluent in English (see explanation in Section 7.0 Assessment / Evaluation Plan -
Language Determination);

- Has a diagnosis of breast cancer (Stage I-III);

- Is treatment naïve and scheduled to receive chemotherapy, radiation, or endocrine
therapy.

Healthy Control Subject Inclusion Criteria

- Is at least 18 years old, but not older than 61 years old;

- Is female;

- Is Hispanic or Black Non-Hispanic;

- Is fluent in English

Exclusion Criteria:

- Participants with neurologic illnesses affecting cognition, (i.e., Traumatic Brain
Injury with a loss of consciousness >30 min., etc.) or severe psychiatric illness
(i.e., schizophrenia, bipolar disorder, etc.);

- A hearing or visual deficit that impairs the ability to participate in the EEG tasks.

- Any condition which prevents application of the 160 EEG electrodes spaced evenly
across the participant's scalp, which includes dreadlocks, and hair extensions
applied by weaving, braiding, gluing, or clips-. unless the participants are willing
to undo these styles prior to the EEG.

- Mini-Mental State Exam (MMSE) <16 (telephone version); MMSE <20 (in-person version)

- Prior chemotherapy for any malignancy

- Regularly taking opiates or take a daily, morning benzodiazepine or have taken a prn
benzodiazepine prior to the assessment.

Healthy Control Subject Exclusion Criteria

- Current or historical cancer diagnosis (a previous diagnosis of basal cell skin
carcinoma is allowable)

- History of neurologic illnesses affecting cognition, (i.e., Traumatic Brain Injury
with a loss of consciousness >30 min., etc.) or severe psychiatric illness (i.e.,
schizophrenia, bipolar disorder, etc.);

- A hearing or visual deficit that impairs the ability to participate in the EEG tasks.

- Any condition which prevents application of the 160 EEG electrodes spaced evenly
across the participant's scalp, which includes dreadlocks, and hair extensions
applied by weaving, braiding, gluing, or clips-. unless the participants are willing
to undo these styles prior to the EEG

- Mini-Mental State Exam (MMSE) <16 (telephone version); MMSE <20 (in-person version)

- Regularly taking opiates or takes a daily, morning benzodiazepine or has taken a prn
benzodiazepine prior to the assessment.