For additional information, please contact the BMS oncology clinical trial information
service at 855-216-0126 or email MyCancerStudyConnect@emergingmed.com. Please visit
www.BMSStudyConnect.com for more information on clinical trial participation.

Inclusion Criteria:

1. Signed Written Informed Consent

- The signed informed consent form

2. Target Population

- Subjects with advanced and/or metastatic solid tumors or B-NHL who are either
refractory to or have relapsed from standard therapies, or for whom a standard
therapy does not exist with measurable disease per Response Evaluation Criteria
in Solid Tumors (RECIST) 1.1 criteria

- Life expectancy of 12 weeks or greater

- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1

- Adequate organ and marrow function

- For certain subjects, willing and able to provide pre- and post-treatment fresh
tumor biopsies

3. Age and Reproductive Status

- Women of childbearing potential (WOCBP) and men must be using an acceptable
method of contraception to avoid pregnancy throughout the study and for at least
4 weeks prior to initiation of dosing, and for at least 60 days after the last
dose of investigational product in such a manner that the risk of pregnancy is
minimized

- WOCBP must have a negative serum or urine pregnancy test [minimum sensitivity 25
UI/L or equivalent units of human chorionic gonadotrophin (HCG)] within 24 hours
prior to the start of investigational product

- Women must not be breastfeeding

Exclusion Criteria:

1. Target Disease Exceptions

- Subjects with known or suspected brain metastasis unless previously treated and
without evidence of progression

- Subjects with a history of prior malignancy active within the previous 2 years
except for locally curable cancers that have been apparently cured

- Subjects with hepatocellular carcinoma

2. Medical History and Concurrent Diseases

- Any active autoimmune disease or documented history of autoimmune disease, or
history of syndrome that required systemic steroids or immunosuppressive
medications, except for subjects with vitiligo, psoriasis inactive within past 2
years, resolved childhood asthma/atopy, or thyroid disease controlled by
replacement therapy without the need for immunosuppression

- Known or suspected human immunodeficiency virus (HIV) or hepatitis A(acute), B
or C infection

- History of any hepatitis (e.g., alcohol or non-alcohol steatohepatitis (NASH),
drug-related, auto-immune)

- Evidence of active infection, requiring parenteral anti-bacterial, anti-viral or
anti-fungal therapy < 7 days prior to administration of study medication

- History of clinically significant cardiac disease, including but not limited to
a history (personal or family) of congenital long QT syndrome

- Grade > 1 QTc prolongation at baseline (> 450 msec by Bazett formula) confirmed
by a repeat electrocardiogram (ECG)

- History of myocardial infarction or uncontrolled angina within 12 months prior
to administration of study drug

3. Physical and Laboratory Test Findings

- WOCBP who are unwilling or unable to use an acceptable method to avoid pregnancy
for the entire study period and for up to 12 weeks after the last dose of
investigational product

- Women who are pregnant or breastfeeding

- Women with a positive pregnancy test on enrollment or prior to investigational
product administration

- Sexually active fertile men not using effective birth control if their partners
are WOCBP

- Positive blood screen for hepatitis A IgM, hepatitis C antibody, hepatitis B
surface antigen, or HIV-1, -2 antibody

4. Allergies and Adverse Drug Reaction

- History of allergy to Urelumab (BMS-663513) or related compounds

- History of significant drug allergy (such as anaphylaxis or hepatotoxicity) to a
prior biologic therapy

5. Prohibited Treatments and/or Therapies

- The systemic use of the following therapies are prohibited within 28 days of
first dose of study medication, or longer where indicated:

1. Use of anti-cancer treatment (including investigational drugs) within 28
days

2. Immunosuppressive medications or immunosuppressive doses of systemic
corticosteroids

3. Surgery (except minor surgeries,e.g., biopsies) or radiotherapy

4. Any non-oncology live viral vaccine therapies used for the prevention of
infectious diseases.

- Prior treatment with anti-programmed death 1 (anti-PD-1)/Programmed cell death 1
ligand 1 (PD-L1) or anti-CD137

- Any subject with the following reported drug-related adverse events on anti-
Cytotoxic T-Lymphocyte Antigen 4 (anti-CTLA4) will not be permitted on study:
hepatic, diarrhea/colitis or endocrine adverse events (AE)s Grade ≥ 2, any other
non-laboratory immune-related AE ≥ Grade 3. Subjects must have minimum 9 week
washout period between the last dose of anti-CTLA4 and the first dose Urelumab
(BMS-663513)

- Prior organ allograft or allogeneic bone marrow transplantation

6. Other Exclusion Criteria

- Prisoners or subjects who are involuntarily incarcerated