Inclusion Criteria:

- Patients must have histologically confirmed islet cell carcinoma (PNET) not amenable
to surgical resection

- Patients may have had 0-2 prior therapies; prior chemoembolization or local ablative
therapies are permitted if completed >= 6 weeks prior to study enrollment

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status =<
2

- Patients must have a life expectancy > 3 months

- Patients must have radiographically measurable disease as defined by Response
Evaluation Criteria in Solid Tumors (RECIST) version 1.1 criteria

- Patients' baseline blood pressure must be adequately controlled with or without
antihypertensive medications prior to enrollment (systolic < 140 mmHg, diastolic < 90
mmHg)

- Patients must have left ventricular ejection fraction (LVEF) >= 50 as measured by
echocardiogram or multi gated acquisition scan (MUGA)

- Absolute neutrophil count (ANC) >= 1,500/µL

- Platelets >= 100,000/µL

- Hemoglobin >= 9.0 g/dL

- Total bilirubin =< 2 mg/dL or =< 1.5 times upper limit of normal (ULN)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and
alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) =< 5
times ULN

- International normalized ratio (INR) =< 1.2 times upper limit of normal (ULN);
subjects receiving anticoagulant therapy are eligible if their INR is stable and
within the recommended range for the desired level of anticoagulation

- Activated partial thromboplastin time (aPTT) =< 1.2 x ULN

- Albumin >= 2.8 g/dL

- Serum creatinine =< 1.5 times ULN OR if serum creatinine >= 1.5 mg/dL, calculated
creatinine clearance >= 30 mL/min

- Urine protein to creatinine ratio < 1 OR 24-hour urine protein < 1 g

- Patients must be able to tolerate oral medications

- Females of child-bearing potential must have a negative pregnancy test within 14 days
of study enrollment and must agree to use an effective method of birth control during
treatment and for three months after receiving their last dose of study drug; males
must agree to use an effective method of birth control during treatment and for three
months after receiving their last dose of study drug; all patients must notify
treating provider immediately if any suspicion of pregnancy or conception;

- Child-bearing potential is defined as any woman (regardless of sexual orientation,
having undergone a tubal ligation, or remaining celibate by choice) who meets the
following criteria: has NOT undergone a hysterectomy or bilateral oophorectomy; OR
has NOT been naturally postmenopausal for at least 12 consecutive months (i.e., has
had menses at any time in the preceding 12 consecutive months)

- The eligibility of patients receiving any medications or substances known or with
potential to affect the activity or pharmacokinetics of temozolomide and/or pazopanib
will be determined following review of the case by the Principal Investigator and the
Data Monitoring Committee (DMC); efforts should be made to switch patients who are
taking enzyme-inducing agents to other medications

- Patients must have given signed, informed consent prior to registration on study

Exclusion Criteria:

- Patients taking immunosuppressive medications (including systemic corticosteroids
unless used for adrenal replacement), appetite stimulants, acute therapy for asthma
or acute bronchitis exacerbation, or antiemetics are NOT eligible for participation

- Patients with known human immunodeficiency virus (HIV) infection are NOT eligible for
participation

- Patients with uncontrolled hypertension (>= 140/90 mmHg) are NOT eligible for
participation

- Patients with uncontrolled hyperlipidemia (total cholesterol > 350 or triglycerides >
300) are NOT eligible for participation

- Patients who have had a transfusion within 7 days of screening are NOT eligible for
participation

- Patients with symptomatic brain or bone metastasis (mets) are NOT eligible for
participation; prior radiation and/or steroid therapy for brain or bone mets must be
completed >= 2 weeks prior to study enrollment

- Patients with a history of seizure disorder requiring antiepileptic medication or
brain metastases with seizures are NOT eligible for participation

- Patients with an active second malignancy (other than non-melanoma skin cancer or
cervical carcinoma in situ) are NOT eligible for participation; patients who have a
history of malignancy are not considered to have a currently active malignancy if
they have completed therapy and are now considered by their physician to be at < 30%
risk for relapse

- Patients with clinically significant gastrointestinal abnormalities that may increase
the risk for gastrointestinal bleeding are NOT eligible for participation; these may
include (but are not limited to):

- Active peptic ulcer disease

- Known intraluminal metastatic lesion/s with risk of bleeding

- Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)

- Other gastrointestinal conditions with increased risk of perforation

- Patients with a history of abdominal fistula, gastrointestinal perforation, or
intra-abdominal abscess within 28 days prior to beginning study treatment are NOT
eligible for participation

- Patients with clinically significant gastrointestinal abnormalities that may affect
absorption of the investigational product including are NOT eligible for
participation; these may include (but are not limited to):

- Malabsorption syndrome

- Major resection of the stomach or small bowel

- Patients with a history of any one or more of the following cardiovascular conditions
within the past 6 months prior to study enrollment are NOT eligible for
participation:

- Cardiac angioplasty or stenting

- Myocardial infarction

- Unstable angina

- Coronary artery bypass graft surgery

- Symptomatic peripheral vascular disease

- Class III or IV congestive heart failure, as defined by the New York Heart
Association

- Patients with a corrected QT interval (QTc) > 480 msecs are NOT eligible for
participation

- Patients with a history of transient ischemic attack (TIA) or cerebrovascular
accident (CVA) within the past 6 months prior to study enrollment are NOT eligible
for participation

- Patients with a history of any one or more of the following thromboembolic events
within the past 6 months prior to study enrollment are NOT eligible for
participation:

- Pulmonary embolism

- Untreated deep venous thrombosis (DVT); subjects with recent DVT who have been
therapeutically coagulated for at least 6 weeks ARE eligible

- Patients who have undergone major surgery or trauma within 28 days prior to the first
dose of investigational product and/or present with any non-healing wound, fracture,
or ulcer are NOT eligible for participation; procedures such as catheter placement
not considered to be major surgery

- Patients with known endobronchial lesions and/or lesions infiltrating major pulmonary
vessels that increase the risk of pulmonary hemorrhage are NOT eligible for
participation

- Lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are
excluded; however, the presence of a tumor that is touching, but not infiltrating,
the vessels is acceptable; CT with contrast is strongly recommended to evaluate such
lesions

- Large protruding endobronchial lesions in the main or lobar bronchi are excluded;
however, endobronchial lesions in the segmented bronchi are allowed

- Lesions extensively infiltrating the main or lobar bronchi are excluded; however,
minor infiltrations in the wall of the bronchi are allowed

- Patients who have had recent hemoptysis (>= 1/2 teaspoon of red blood within 8 weeks
before first dose of study drug) are NOT eligible for participation

- Patients who have any history of allergic reaction(s) attributed to compounds of
similar composition to temozolomide, pazopanib, their metabolites, or any component
of their formulation are NOT eligible for participation

- Females who are pregnant or lactating, fertile males, or females of child-bearing
potential who are not willing to comply with an effective double method of birth
control are NOT eligible for participation

- Patients with a psychiatric illness, other condition or significant medical illness,
or social situation which, in the investigator's opinion, would limit compliance or
ability to comply with study requirements are NOT eligible for participation

- Patients who have taken medications that are known strong inducers or inhibitors of
Cytochrome P450 3A4 (CYP3A4) within 28 days prior to registration are NOT eligible
for participation