Inclusion Criteria:

1. Pathologically confirmed solid tumor preferably, but not exclusively, including
pancreatic, thyroid, colorectal, non-small cell lung, endometrial, renal, breast,
ovarian carcinoma, or melanoma which is locally advanced or metastatic, and either
refractory after standard therapy for the disease or for which no effective standard
therapy is available.

2. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of ≤ 1.

3. Has read and understands the informed consent form and is willing and able to give
informed consent. Fully understands requirements of and willing to comply with all
trial visits and assessments.

4. Evidence of measurable disease at trial entry as per Response Evaluation Criteria In
Solid Tumors (RECIST) v1.0.

5. Willing to provide archival tissue samples for molecular analysis.

Other inclusion criteria also apply.

Exclusion Criteria:

1. Bone marrow impairment as evidenced by hemoglobin < 9.0 g/dL, neutrophil count < 1.5
x 10^9/L, and/or platelets < 100 x 10^9/L.

2. Renal impairment as evidenced by serum creatinine > 1.5 x ULN (upper limit of normal)
and/or calculated creatinine clearance < 50 mL/min (Cockcroft-Gault formula).

3. Liver function and liver cell integrity abnormality as defined by total bilirubin>
1.5 x ULN, or aspartate aminotransferase/alanine aminotransferase (AST/ALT) > 2.5 x
ULN, for subjects with liver involvement AST/ALT > 5 x ULN. Subjects with albumin <
2.5 g/dL are also excluded.

4. History of central nervous system (CNS) metastases..

5. History of difficulty of swallowing, malabsorption, or other chronic gastrointestinal
disease or conditions that may hamper compliance and/or absorption of the tested
product.

6. Chronic diarrhea that is ≥ Grade 2 in severity

7. Clinically significant cardiac conduction abnormalities.

8. A left ventricular ejection fraction of < 45%.

9. A history of stroke or myocardial infarction within the past year.

10. A history of uveitis and scleritis.

11. Retinal pathology beyond normal age-related processes.

12. Evidence of a retinal vein occlusion on fluorescein angiogram or a history of retinal
vein occlusion.

Subjects are also excluded if their ophthalmologist finds that their optic disc is at
risk for a central retinal vein occlusion.

13. History of glaucoma.

14. Subjects requiring daily and/or chronic systemic steroids.

15. Pregnant or nursing females.

Other exclusion criteria also apply.