Ovarian Aging in Women Newly Diagnosed With Low Grade Glioma Treated With Temozolomide (Temodar®)

Inclusion Criteria:

- Premenopausal women ages 18-44 newly diagnosed with LGG

- Patients fulfill the inclusion criteria for UCSF Protocol Number: CC #99102 " A
Phase II Study of Temozolomide (TEMODAR) in the Treatment of Adult Patients with
Supratentorial Low Grade Glioma"

- Patients with histologically proven supratentorial low grade glioma.

- Patients may or may not have had a surgical resection.

- Patients must be expected to live the length of study

- Patients must be able to provide informed consent according to institutional
guidelines.

Exclusion Criteria:

- Prior ovarian resection, unilateral or bilateral oophorectomy, hysterectomy or
radiation to pelvic region.

- Pregnancy or breast feeding.

- Diagnosis of another malignancy, unless the patient was diagnosed at least 2 years
earlier and has been disease-free for at least 6 months following the completion of
curative intent therapy with the following exceptions: Patients with treated
non-melanoma skin cancer, in situ carcinoma, or cervical intraepithelial neoplasia,
regardless of the disease-free duration, are eligible for this study if definitive
treatment for the condition has been completed.

- Any significant concurrent disease, illness, or psychiatric disorder that would
compromise patient safety or compliance, interfere with consent, study participation,
follow up, or interpretation of study results.

- Patients with a systemic fungal, bacterial, viral, or other infection not controlled
(defined as exhibiting ongoing signs/symptoms related to the infection and without
improvement, despite appropriate antibiotics or other treatment).

- Patient is, at the time of signing informed consent, a regular user (including
"recreational use") of any illicit drugs, substance abuse or had a recent history
(within the last year) of drug or alcohol abuse

- Patient has a history or current evidence of any condition, therapy, or lab
abnormality that might confound the results of the study, interfere with the
patient's participation for the full duration of the study or is not in the best
interest of the patient.