Inclusion Criteria:

- Documented insufficient serum levels of 25-hydroxyvitamin D =< 30.0 ng/mL

- At least moderate sun-damaged skin on the mid-upper right dorsal forearm

- Karnofsky performance status of at least 80%

- Leukocytes âÃÂ¥ 3,000/ÃüL

- Absolute neutrophil count âÃÂ¥ 1,500/ÃüL

- Platelets âÃÂ¥ 100,000/ÃüL

- Total bilirubin âä 2.0 mg/dL

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT])
=< institutional upper limit of normal (ULN)

- Creatinine âä 1.4 mg/dL

- Serum calcium 8.4-10.6 mg/dL

- Parathyroid hormone (PTH): male 8.3-10.4 mg/dL; female 8.4-10.6 mg/dL

- Women of child-bearing potential must agree to use adequate contraception (hormonal
or barrier method of birth control; abstinence; surgical sterilization; or at least
one year post-menopausal) prior to study entry and for the duration of study
participation

- Skin phototype II or III as defined according to their skin response to sunlight:

- Skin phototype II will always burn, and tan minimally after 45-60 min of
unprotected exposure to the summer sun between 12-1pm

- Skin phototype III will sometimes burn, and almost always tan after 45-60 min of
unprotected exposure to the summer sun between 12-1pm

- Ability to understand and willingness to sign written informed consent

- Participants may not have acute or chronic hypervitaminosis D or hypercalcemia

- No history of increased arterial calcification or atherosclerosis, sarcoidosis,
histoplasmosis, hyperparathyroidism, lymphoma, or kidney disease

- No current use of digoxin (Lanoxin, digitalis), cholestyramine (Prevalite, Questran),
colestipol (Cholestid), oral steroids (prednisone and others), and antacids that
contain magnesium

- Participants may not be receiving any other investigational agents; if they have
completed a clinical-intervention trial recently, there must be a 30-day period
between completing the previous study and entering this study

- No history of allergic reactions attributed to compounds of similar chemical or
biologic composition to cholecalciferol, lidocaine, or xylocaine

- No uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant and breastfeeding women are excluded from this study

- No invasive cancer or cancer treatment within the past five years, except
non-melanoma skin cancer

- No immunosuppression by virtue of medication or disease; this includes acquired
immune deficiency syndrome (AIDS) patients, subjects taking oral prednisone, and
subjects on immunosuppressants/immunomodulators (cyclosporine, chemotherapeutic
agents, or biologic therapy), as determined by the examining
investigator/co-investigator

- Unwilling or unable to refrain from taking herbal medicines or above-standard vitamin
or mineral during the study

- A standard daily multivitamin/mineral supplement is acceptable if it contains
̉̊ 600 IU of vitamin D, or ̉̊ the recommended dietary allowance
(RDA) of calcium, and the subject has been taking a stable dose for at least 30
days

- Potential subjects who are taking above-standard doses of supplements may be
re-considered for participation after a 30-day wash-out period

- No participants who have used tanning beds or other methods to promote sun-tanning
within 6 months of study entry; such practices may not be undertaken during
participation in the study

- Participants unwilling to minimize their exposure to sunlight by applying
sunscreen/sunblock or by wearing clothing to shield their skin, during outdoor
activities, while they are enrolled in the study

- Individuals receiving concurrent topical therapy with retinoids, steroids,
5-fluorouracil, Levulan, Vaniqa (eflornithine), Solaraze, or Imiquimod
(AldaraÃÃî) within 30 days prior to study enrollment will be excluded; subjects may
be reconsidered for eligibility 30 days after the last treatment

- Individuals who have had treatment for basal cell carcinoma or squamous cell
carcinoma on the skin of the right forearm within six months prior to
evaluation for the study will not be eligible; these subjects will be encouraged to
return for re-evaluation once the six-month period is over