Pilot Study of Model Based Iterative Reconstruction Using 64-Slice Multidetector-Row CT Datasets Obtained From the Central Nervous System, Thorax, and Abdomen

Inclusion Criteria:

- Men or Women 30 years of age or older voluntarily willing to sign an informed
consent.

- Patients indicated for one of the following:

CNS: Known or suspected pathology in the posterior fossa Thorax: Patients referred for
staging of a known or suspected lung cancer Abdomen: Patients with acute flank pain and
suspected urolithiasis or Abdomen: Patients with a known or suspected focal liver lesion

Exclusion Criteria:

- Subjects less than 30 years of age

- Pregnant women as confirmed by urine test or current accepted institution standard

- If IV contrast is required:

- Severe or uncontrolled allergy to iodinated contrast media

- Serum creatinine > 1.7 mg/dl or estimated glomerular filtration rate [eGFR] of <60
mg/min as recorded in medical file or by current accepted institution standard

- Unable or unwilling to provide written informed consent by self or legal guardian at
the time of study enrollment

- Unstable physical condition as identified by physician