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Allogeneic Hematopoietic Progenitor Cell Transplantation From Unrelated Donors


N/A
18 Years
69 Years
Open (Enrolling)
Both
Severe Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Myeloproliferative Syndromes, Chronic Myelogenous Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Large Granulocytic Leukemia

Thank you

Trial Information

Allogeneic Hematopoietic Progenitor Cell Transplantation From Unrelated Donors


Inclusion Criteria:



- > 18 years of Age

- < 70 years

- ECOG performance status 0, 1 or 2

- Left Ventricular Ejection Fraction > 30%

- Creatinine clearance > 40ml/min

- Transaminases < 2X normal

- Total bilirubin < 2X normal

- HIV seronegativity

- Weight < 70kg for cord blood transplantation

Exclusion Criteria:

- Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at
HLA-A, B, C or DR

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Bone Marrow and Peripheral Blood Chimerism

Outcome Description:

Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.

Outcome Time Frame:

30 days post-transplant

Safety Issue:

No

Principal Investigator

Jeffrey W. Andrey, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Scripps Clinic Medical Group

Authority:

United States: Institutional Review Board

Study ID:

HSC-03-2329

NCT ID:

NCT01364363

Start Date:

March 2005

Completion Date:

January 2023

Related Keywords:

  • Severe Aplastic Anemia
  • Paroxysmal Nocturnal Hemoglobinuria
  • Acute Myelogenous Leukemia
  • Acute Lymphoblastic Leukemia
  • Myelodysplastic Syndromes
  • Myeloproliferative Syndromes
  • Chronic Myelogenous Leukemia
  • Hodgkin's Lymphoma
  • Non-Hodgkin's Lymphoma
  • Multiple Myeloma
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Large Granulocytic Leukemia
  • Transplant
  • Allogeneic
  • Allogeneic transplant
  • Unrelated donor transplant
  • MUD
  • HSCT
  • Stem cell transplant
  • Anemia
  • Anemia, Aplastic
  • Hemoglobinuria
  • Hodgkin Disease
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Hemoglobinuria, Paroxysmal
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Myelodysplastic Syndromes
  • Preleukemia
  • Myeloproliferative Disorders

Name

Location
Scripps Green Hospital La Jolla, California  92037