Trial Information
Allogeneic Hematopoietic Progenitor Cell Transplantation From Unrelated Donors
Inclusion Criteria:
- > 18 years of Age
- < 70 years
- ECOG performance status 0, 1 or 2
- Left Ventricular Ejection Fraction > 30%
- Creatinine clearance > 40ml/min
- Transaminases < 2X normal
- Total bilirubin < 2X normal
- HIV seronegativity
- Weight < 70kg for cord blood transplantation
Exclusion Criteria:
- Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at
HLA-A, B, C or DR
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Bone Marrow and Peripheral Blood Chimerism
Outcome Description:
Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.
Outcome Time Frame:
30 days post-transplant
Safety Issue:
No
Principal Investigator
Jeffrey W. Andrey, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Scripps Clinic Medical Group
Authority:
United States: Institutional Review Board
Study ID:
HSC-03-2329
NCT ID:
NCT01364363
Start Date:
March 2005
Completion Date:
January 2023
Related Keywords:
- Severe Aplastic Anemia
- Paroxysmal Nocturnal Hemoglobinuria
- Acute Myelogenous Leukemia
- Acute Lymphoblastic Leukemia
- Myelodysplastic Syndromes
- Myeloproliferative Syndromes
- Chronic Myelogenous Leukemia
- Hodgkin's Lymphoma
- Non-Hodgkin's Lymphoma
- Multiple Myeloma
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
- Large Granulocytic Leukemia
- Transplant
- Allogeneic
- Allogeneic transplant
- Unrelated donor transplant
- MUD
- HSCT
- Stem cell transplant
- Anemia
- Anemia, Aplastic
- Hemoglobinuria
- Hodgkin Disease
- Leukemia
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukemia, Lymphoid
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lymphoma
- Lymphoma, Non-Hodgkin
- Hemoglobinuria, Paroxysmal
- Multiple Myeloma
- Neoplasms, Plasma Cell
- Myelodysplastic Syndromes
- Preleukemia
- Myeloproliferative Disorders
Name | Location |
Scripps Green Hospital |
La Jolla, California 92037 |